MindSet: the Manitoba Integrative Data Platform
The conduct of ICU research trials is typically constrained by the difficulty and expense of collecting data expressly for the purpose of the study. Recent, standard, investigator-driven efficacy RCTs done by the Canadian Critical Care Trials Group have cost in the range of $3-7 million, and industry-driven Phase 3 drug trials in sepsis cost tens of millions of dollars, or more.
There is an increasing recognition that many RCTs can be done primarily using routinely collected medical data. Such studies can be much easier and less expensive to perform. These mandate the ability to acquire these data elements in real-time (or near real-time), but patients' medical records (whether paper or electronic) typically take weeks or longer to become complete after hospital discharge. Thus, to gain the benefits of such trials, it is necessary to have a real-time data repository where the data of all types (clinical laboratory, radiology, electronic medical record, etc) are automatically deposited, cleaned and maintained.
Towards this, Dr. Ryan Zarychanski is the nominated Principal Investigator for over $6 million in funding – from combination of the Canadian Institutes for Health Research, the Province of Manitoba, The University of Manitoba, CancerCare Manitoba and others – to develop such a data repository in the province. Once complete, this resource will greatly facilitate conducting a wide range of human clinical studies relating – but not limited to – critical illness.