St. Andrew's College in Winnipeg traces its beginnings to Pastoral Courses in Theology that were conducted in Saskatoon and Regina since 1918. In 1932, Pastoral Courses in Theology evolved into the Seminary of the Ukrainian Greek-Orthodox Church of Canada and moved to Winnipeg. A concrete plan for the establishment of a College, a higher institution of learning, was presented to and approved by the Clergy Conference of the Ukrainian Greek-Orthodox Church of Canada on June 25, 1943. Subsequently, St. Andrew's College was incorporated under its charter in September 1946 on the premises of the former St. John's College (Anglican) on Church Avenue in Winnipeg.

Church leaders decided to move the institution to the University of Manitoba campus. In 1960, negotiations were initiated with the University of Manitoba, culminating on June 14, 1962 when St. Andrew's College became an associated college of the University. Construction of a new building on the campus began in December 1962 and was completed in the spring of 1964.