Professor
Max Rady College of Medicine
Medical Microbiology & Infectious Diseases
Room 795 - 715 McDermot Ave.
University of Manitoba
Winnipeg, Manitoba R3E 3P4
The University of Manitoba campuses are located on original lands of Anishinaabeg, Cree, Oji-Cree, Dakota, and Dene peoples, and on the homeland of the Métis Nation. More
University of Manitoba
Winnipeg, Manitoba Canada, R3T 2N2
Max Rady College of Medicine
Medical Microbiology & Infectious Diseases
Room 795 - 715 McDermot Ave.
University of Manitoba
Winnipeg, Manitoba R3E 3P4
Molecular delineation of:
Research scientist, Children’s Hospital Research Institute of Manitoba (CHRIM)
Our laboratory studies virus structure, function, assembly, and pathogenesis. We use biologic, molecular genetic, and mass spectrometric methods to elucidate how mammalian reoviruses, avian reoviruses, human coronaviruses, Influenza A viruses, and Zika viruses interact with various host cells as models for understanding how multiple proteins and nucleic acids recognize each other and interact to generate a functionally active macromolecular complex, how these complexes interact with host cellular proteins, and how these interactions can be exploited through use of selected anti-viral agents to attenuate virus-induced infection and pathogenesis.
Dr. Kevin Coombs is a professor in medical microbiology and infectious diseases at the University of Manitoba.
Dr. Coombs’ major research interests are to delineate the protein and nucleic acid interactions in nucleoprotein complexes, using a variety of RNA viruses as models. His lab studies how these interactions change as a result of, and in turn, are modulated by, conformational transitions that occur during macromolecular assembly and disassembly, how these processes can be attenuated by anti-viral compounds, and how these processes in virus infections contribute to pathogenesis in the host. This work, which has been continuously funded by the MRC/CIHR since the year after he moved to Manitoba, is in general areas of:
Dr. Coombs has served on numerous local, national, and international grant funding panels. He has served in a variety of administrative roles, including as Chair for the CIHR Virology and Viral Pathogenesis panel, as acting and associate head for the department of medical microbiology; as associate dean, Faculty of Graduate Studies; and as associate and assistant dean of research in the Max Rady College of Medicine.
Medical Microbiology and Infectious Diseases
Max Rady College of Medicine
Room 543 - 745 Bannatyne Avenue
University of Manitoba (Bannatyne campus)
Winnipeg, MB R3E 0J9 Canada