Rady Faculty of Health Sciences

MR/PET-MR Imaging

This state-of-the-art imaging system provides the flexibility to perform experiments on rats and mice in three configurations:

  • stand-alone PET
  • stand-alone MRI
  • sequential PET-MRI
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Overview

The core of the MRI component is a 7T cryogen free superconducting magnet with a 17 cm bore.

The cryogen free magnet imparts a small footprint and low mass to the MRI system, ensuring that it could be installed in our existing imaging facility with little or no renovation.

At the core of the PET component are two rings of dual layer silicon photomultiplier (lutetium-yttrium oxyorthosilicate) detectors forming a compact and robust PET imaging system that can be operated as a stand-alone PET imaging system or attached to the face of the MRI to operate as a sequential PET-MRI imaging system.

This new system therefore provides users the flexibility to conduct MR, PET, or PET-MR experiments.

Examples

Mouse brain

This figure  shows T1 and T2 images obtained from a mouse with tumour cells implanted in the cerebellum. Images were acquired with a quadrature bird cage head coil.

 Diffusion tensor imaging of the rat brain

Images were acquired with a quadrature bird cage 42 mm inner diameter x 28 mm length.

 

MR Angiography

Images were acquired with a quadrature bird cage 42 mm inner diameter x 28 mm length.

 

Scan of a mouse brain.
Diffusion tensor imaging of the rat brain.
7T MRI Example - MR Angiography.

Instrumentation

Configuration 1

Stand-alone MRI with motion-controlled bed and physiological monitoring to allow respiratory and cardiac gating.

Confiiguration 2

Stand-alone PET with motion-controlled bed and physiological monitoring to allow respiratory and cardiac gating.

Configuration 3

Sequential PET-MRI with motion-controlled bed and physiological monitoring to allow respiratory and cardiac gating. Precise motion control allows registration of PET and MR images post-acquisition.

MR PET-MR Instrumentation configuration 1.
Stand-alone PET with motion-controlled bed and physiological monitoring to allow respiratory and cardiac gating.
MR PET-MR Instrumentation configuration 3.

Additional information

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Applications

Applications include:

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Pricing information

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Resources

The materials listed here are available for investigators by request.

Adjusting RF calibration

Animal handling instructions

Image display user manual

MRS preclinical scan manual

PCSAM manual

PowerScan user manual

Reading noise level

Sequence library

Contact us

Central Animal Core Imaging and Transgenic Facilities
23 Basic Medical Sciences Building
745 Bannatyne Avenue
University of Manitoba
Winnipeg, MB R3E 0J9 Canada

Transgenic services: transgenicservice@umanitoba.ca

Imaging services: SAMICF@umanitoba.ca