College of Pharmacy research theme

  • Molecular Biotherapeutics


  • Immunometabolism
  • Fatty acids
  • Metabolic disease
  • Monocytes
  • Macrophages
  • Inflammation

Research summary

Inappropriate activation of innate immune cells such as monocytes and macrophages contributes to the development and progression of chronic diseases including obesity, type 2 diabetes mellitus, and cardiovascular disease.

Emerging evidence suggests that innate immune cell activation is closely linked to the metabolic state of the cell, that is, the metabolic pathways it uses to break down, produce, and store macronutrients.

The aims of my lab are:

  • to characterize the relationships between innate immune cell metabolism and metabolic disease, and
  • to explore pharmacological and dietary interventions that could restore health by targeting immune-metabolic pathways.



Dr. Samantha Pauls has a strong background in cross-disciplinary research involving immunobiology, lipid biology and metabolic disease. She completed a PhD in Biochemistry and Medical Genetics at the University of Manitoba in 2016 then received further training as a postdoctoral fellow at the Canadian Centre for Agri-Food Research in Health and Medicine (CCARM) before joining the College of Pharmacy in 2021.

In addition to her research role, she is committed to supporting the professional development of all graduate students in the Rady Faculty of Health Sciences, enabling their transition into successful, fulfilling careers.

Contact us

College of Pharmacy
Apotex Centre
750 McDermot Avenue West
University of Manitoba (Bannatyne campus)
Winnipeg, MB R3E 0T5 Canada