Assistant professor
College of Pharmacy
Apotex Centre, 750 McDermot Ave. W.
University of Manitoba
Winnipeg, MB R3E 0T5
Phone: 204-789-3586
Fax: 204-798-3744
samantha.pauls@umanitoba.ca
Samantha Pauls, PhD
College of Pharmacy research theme
- Molecular Biotherapeutics
Keywords
- Immunometabolism
- Fatty acids
- Metabolic disease
- Monocytes
- Macrophages
- Inflammation
Research summary
Inappropriate activation of innate immune cells such as monocytes and macrophages contributes to the development and progression of chronic diseases including obesity, type 2 diabetes mellitus, and cardiovascular disease.
Emerging evidence suggests that innate immune cell activation is closely linked to the metabolic state of the cell, that is, the metabolic pathways it uses to break down, produce, and store macronutrients.
The aims of my lab are:
- to characterize the relationships between innate immune cell metabolism and metabolic disease, and
- to explore pharmacological and dietary interventions that could restore health by targeting immune-metabolic pathways.
Biography
Dr. Samantha Pauls has a strong background in cross-disciplinary research involving immunobiology, lipid biology and metabolic disease. She completed a PhD in Biochemistry and Medical Genetics at the University of Manitoba in 2016 then received further training as a postdoctoral fellow at the Canadian Centre for Agri-Food Research in Health and Medicine (CCARM) before joining the College of Pharmacy in 2021.
In addition to her research role, she is committed to supporting the professional development of all graduate students in the Rady Faculty of Health Sciences, enabling their transition into successful, fulfilling careers.
Contact us
College of Pharmacy
Apotex Centre
750 McDermot Avenue West
University of Manitoba (Bannatyne campus)
Winnipeg, MB R3E 0T5 Canada
204-474-9306
204-789-3744