• Thomas Klonisch headshot
  • Professor

    Max Rady College of Medicine
    Human anatomy and cell science
    University of Manitoba
    Room 130 – Basic Medical Sciences Building
    745 Bannatyne Avenue
    Winnipeg, Manitoba, R3E 0J9

    Phone: 204-789-3893
    Laboratory phone: 204-789-3981
    Fax: 204-789-3920

Research summary

Dr. Thomas Klonisch's research program is focused on uncovering new and innovative ways to treat adult brain tumors. His team is at the forefront of developing cutting-edge treatments that can overcome the challenging barrier of the blood-brain barrier, allowing them to specifically target brain tumors and the cells within the tumor microenvironment. Dr. Klonisch and his team are also working on new strategies to block the cellular pathways that are critical for tumor cell survival and they are exploring ways to reprogram innate immune cells to fight brain cancer. Additionally, the team collects patient brain tumor cells and blood for biobanking to enable personalized research. With a focus on uncovering the molecular determinants of brain tumor progression, Dr. Klonisch's research is providing valuable insights into the underlying mechanisms of therapy resistance, opening new doors for the development of novel ABL kinase inhibitors as a brain tumor treatment. His research is making a significant impact in the field and has the potential to change the way we approach the treatment of brain tumors.

  • Research interests

    • Molecular determinants of brain tumor progression
    • Molecular mechanisms of therapy resistance
    • Novel ABL kinase inhibitors for brain tumor treatment
    • Modulating innate immune responses to treat brain tumors

    Research affiliations

    • Adjunct scientist, Research Institute of Cancer and Hematology (RIOH), CancerCare Manitoba

    Research groups

    • Member, Terry Fox Research Institute (TFRI) Prairie Cancer Research Consortium
  • Keywords

    • ABL kinase inhibitors
    • Brain cancer
    • Brain tumors
    • Glioma
    • Innate immune cells
    • Molecular mechanisms
    • Novel treatments
    • Therapy resistance
    • Tumor microenvironment


Dr. Thomas Klonisch is a highly accomplished medical professional who has dedicated his career to understanding and treating adult brain tumors. He received his MD and PhD from the Justus Liebig University of Giessen in Germany, and went on to work at the Institute of Medical Microbiology at the University of Mainz. After receiving a Feodor Lynen Research Fellowship from the Alexander-von-Humboldt Foundation, Dr. Klonisch completed two postdoctoral fellowships at the Ontario Veterinary College and University College London. In 1996, he joined the anatomy and cell biology department at the Martin Luther University of Halle-Wittenberg, where he taught all aspects of anatomy and conducted cancer research. He received certification as an anatomist by the German Anatomical Society in 1999 and completed his Habilitation in 2000. In 2004, he became a full professor and head of the human anatomy and cell science department at the Max Rady College of Medicine. He has served as department head for 15 years.


  • Doctor of Medicine (MD), University of Giessen, Germany (1991)
  • Doctor of Philosophy (PhD), University of Giessen, Germany (1991)


  • Feodor-Lynen Fellowship from the Alexander von Humboldt Foundation, Germany (1991-1992)

Contact us

Human Anatomy and Cell Science
130 Basic Medical Science Building
745 Bannatyne Avenue

University of Manitoba
Winnipeg, MB R3E 0J9 Canada