The University of Manitoba campuses are located on original lands of Anishinaabeg, Ininew, Anisininew, Dakota and Dene peoples, and on the National Homeland of the Red River Métis. More
University of Manitoba
Winnipeg, Manitoba Canada, R3T 2N2
Max Rady College of Medicine
Physiology and Pathophysiology
University of Manitoba
Room SR422 – Kleysen Institute for Advanced Medicine
710 William Avenue
Winnipeg, Manitoba R3E 0Z3
Phone: 204-318-2564
tabrez.siddiqui@umanitoba.ca
Synapse development involves the adhesion of axons and dendrites and the recruitment of presynaptic vesicle release machinery in axons and neurotransmitter receptor machinery in dendrites. Trans-synaptic adhesion proteins, known as synapse organizers, coordinate these processes. These proteins play critical roles in synapse formation, maintenance, and synaptic plasticity. Mutations in genes encoding these proteins can disrupt synaptic function, increasing the risk for disorders like autism and schizophrenia. Dr. Siddiqui's research aims to:
The Siddiqui lab's research will enhance our understanding of neuronal circuit formation and function, potentially leading to novel therapeutics targeting synapse organizers.
Research scientist:
Dr. Tabrez Siddiqui is an associate professor at the University of Manitoba, where he is appointed in the Department of Physiology and Pathophysiology. He trained as a biophysicist and biochemist at the Max Planck Institute for Biophysical Chemistry in Germany. His postdoctoral work at the University of British Columbia focused on neuronal synapse development, contributing significantly to understanding glutamatergic synapses. In 2014, he joined the University of Manitoba. His research focuses on synaptic adhesion and scaffolding molecules. His lab employs various methods, including protein chemistry, glycobiology, molecular genetics, and animal behavior studies.
2013
2011
Physiology and Pathophysiology
432 Basic Medical Sciences Building
745 Bannatyne Avenue
University of Manitoba
Winnipeg, MB R3E 0J9 Canada
