Max Rady College of Medicine
Room 839 – John Buhler Research Centre
715 McDermot Avenue
University of Manitoba
Winnipeg, Manitoba R3E 3P4
Dr. Mishra’s laboratory studies the basic mechanisms involved in the interplay between adipose and immune functions in normal physiology, during aging, and in many diseases. His current research works are directed towards understanding the extent and specificity with which sex hormones, X-linked and autosomal genes/micro-RNAs expression define sex differences in adipose and immune functions, and towards elucidating potential connections between them. Identifying molecular signature of sex differences in adipose and functions expected to improve basic understanding of sex-biased metabolic and immune diseases. Ultimately, it is hoped that such studies will provide insights into why men and women are differently vulnerable to metabolic and immune diseases, and will enable the development of effective sex-tailored therapeutic modalities.
Dr. Mishra is a professor of endocrinology and metabolism in the department of internal medicine. He received his doctorate from the University of Delhi and post-doctoral training at the HSC University of Louisville and University of Manitoba. His laboratory has used an innovative approach to developed preclinical mouse models that spontaneously developed obesity-linked diabetes and tumors independent of diet and carcinogens, which led to successful patent applications to the United States Patent and Trademark Office (USPTO). These findings have provided new insights on the sex differences in obesity-linked metabolic dysregulation and in the development of diabetes and cancer. Recently, he has reported that an evolutionarily conserved pleiotropic protein, prohibitin, plays a role in sex differences in adipose and immune functions.
Recently, he edited a book on Immunometabolism: Methods and Protocols, which is published by Springer Nature as a part of a well-known series on Methods in Molecular Biology. Research in his laboratory is supported by Canada Foundation for Innovation (CFI), Canadian Institutes of Health Research (CIHR), and Natural Sciences and Engineering Research Council of Canada (NSERC).