Associate professor
Max Rady College of Medicine
Human Anatomy and Cell Science
110A-745 Bannatyne Ave
University of Manitoba
Winnipeg, MB R3E 0J9
The University of Manitoba campuses are located on original lands of Anishinaabeg, Cree, Oji-Cree, Dakota, and Dene peoples, and on the homeland of the Métis Nation. More
University of Manitoba
Winnipeg, Manitoba Canada, R3T 2N2
Max Rady College of Medicine
Human Anatomy and Cell Science
110A-745 Bannatyne Ave
University of Manitoba
Winnipeg, MB R3E 0J9
My research career has been focused on the importance of cross talk of three key cellular responses to intra- and extracellular stress in regulation of cellular phenotype including apoptosis, autophagy and unfolded protein response (UPR). We investigate how cellular phenotype is involved in lung cancer metastasis, and chemotherapy response in Glioblastoma and Rhabdomyosarcoma. Our research identifies how autophagy/UPR/apoptosis determine metastatic phenotypes of lung cancer via Bcl2 family proteins. In addition, we address the importance of these three pathways in regulation of chemo-sensitivity of Glioblastoma and Rhabdomyosarcoma cells to different chemotherapy agents.
Dr. Ghavami got his BSc in Chemistry in 1989 (Shiraz University, Shiraz, Iran), MSc and PhD (1995, 2004, TMU University, Tehran, Iran) in Clinical Biochemistry. His Postdoctoral training was focused on the application of apoptosis/autophagy/unfolded protein response (UPR) in regulation of cell fate. His research program is focused on regulation of cellular phenotype via targeting autophagy and UPR at the Department of Human Anatomy and Cell Science, University of Manitoba, He has been the recipient of a number of prestigious awards including CIHR/GSK/CLA postdoctoral award (No. 1 in Canada, 2007), Parker B Francis Career Development Award (top 10 in North America, 2009), ATS Science and Innovation Center Rising Star of Research Award (2017), CIHR/CCS/OICR Early Career Research Award (2017).
Dr. Ghavami is currently, Honorary Professor and co-founder of Autophagy Research Centre at Shiraz University of Medical Science and Tehran University of Medical Sciences, Honorary Professor at Katowice School of Technology, Poland. He is Associate Editor of BBA-Mol Basis of Disease, Molecular Neurobiology, BB Reports and IJMS.
Human Anatomy and Cell Science
130 Basic Medical Science Building
745 Bannatyne Avenue
University of Manitoba
Winnipeg, MB R3E 0J9 Canada