Professor
Max Rady College of Medicine
Human anatomy and cell science
Room 130, Basic Medical Sciences Building
745 Bannatyne Avenue
University of Manitoba
Winnipeg, Manitoba R3E 0J9
Phone: 204-789-3982
sabine.hombach-klonisch@umanitoba.ca
Sabine Hombach-Klonisch, PhD
Cross-appointment
- Pathology, Max Rady College of Medicine
Research summary
Dr. Sabine Hombach-Klonisch's research is at the forefront of understanding the complex mechanisms behind cancer metastasis and treatment resistance. Her team is utilizing cutting-edge techniques such as human cancer cell lines, patient-derived cancer cells, and advanced animal models to gain new insights into how cancer cells invade and spread throughout the body. One of the key areas of focus for her lab is the study of primary and metastatic brain tumors, where they are investigating the unique interactions between the brain's microenvironment and tumor cells.
Her lab is also utilizing single cell analysis to monitor cellular protein interactions, DNA damage responses, and 3D nuclear telomere changes to gain a more detailed understanding of cancer's underlying mechanisms. Her ongoing research projects include studying the nuclear function of the chromatin-remodeling protein HMGA2 in DNA damage sensing and repair, as well as telomere stability. Additionally, she is investigating the tumor-promoting role of novel ligands of the transmembrane G protein-coupled receptor RXFP1 in brain and breast cancer models, which could provide new targets for cancer treatment.
At the Children’s Hospital Research Institute of Manitoba (CHRIM) and through her participation in the Brain Tumor Research Alliance Manitoba (BTRAM), Dr. Hombach-Klonisch is leading a team of researchers that are pushing the boundaries of what is known about cancer metastasis and treatment resistance, and their work has the potential to improve outcomes for cancer patients worldwide.
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Research themes
- Cancer metastasis
- Treatment resistance
Research affiliations and groups
- Children’s Hospital Research Institute of Manitoba (CHRIM)
- Brain Tumor Research Alliance Manitoba (BTRAM)
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Keywords
- Brain cancer
- CTRP8
- DNA damage
- Endoplasmic reticulum stress
- HMGA2
- Relaxin-like peptides
- RXFP1
- Telomere stability
- Treatment resistance
Biography
Dr. Sabine Hombach-Klonisch is a renowned expert in the field of human anatomy and cell science. As a professor at the department of human anatomy and cell science in the Rady College of Medicine at the University of Manitoba, she holds the position of department head and is leading a team of researchers at the forefront of understanding the complex mechanisms behind cancer metastasis and treatment resistance. Her passion for science and her dedication to teaching have earned her numerous awards, including two Teaching Awards for Best Small Group Teaching by the Manitoba Medical Student Association.
Dr. Hombach-Klonisch's journey to becoming a leading researcher in the field of human anatomy and cell science began with her highest academic degree in tumor biology from Martin-Luther University Halle-Wittenberg in Germany. She continued to specialize in human anatomy and received her specialty training in human anatomy from Medical Association of Saxony-Anhalt, Germany. Her extensive research experience and expertise have led to her being recognized with prestigious awards such as Murray L. Barr Young Investigator Award from The Canadian Association for Anatomy, Neurobiology, and Cell Biology and Merck European Thyroid von Basedow Research Prize from German Endocrine Society.
Through her ongoing research projects, Dr. Hombach-Klonisch is making significant contributions to the scientific community, and her work has the potential to improve outcomes for cancer patients worldwide. As a dedicated educator and mentor, she is also passing on her knowledge and passion to the next generation of scientists, ensuring that the future of the field of human anatomy and cell science is in good hands.
Contact us
Human Anatomy and Cell Science
130 Basic Medical Science Building
745 Bannatyne Avenue
University of Manitoba
Winnipeg, MB R3E 0J9 Canada
204-789-3411
204-789-3920