• Naranjan Dhalla headshot
  • Distinguished professor

    Max Rady College of Medicine
    Physiology and Pathophysiology
    University of Manitoba
    Institute of Cardiovascular Sciences
    St. Boniface Hospital Albrechtsen Research Centre 
    Winnipeg, Manitoba R2H 2A6

    Phone: 204-235-3417
    Fax: 204-237-0347
    nsdhalla@sbrc.ca

Cross-appointment

  • Senior fellow, Centre for the Advancement of Medicine 

Research themes 

  • Cardiovascular sciences
  • Pathophysiology of heart disease
  • Experimental cardiology 

Research interests 

  • Molecular and cellular cardiology
  • Diabetic cardiomyopathy
  • Ischemic heart disease
  • Heart failure  

Keywords

  • Heart research
  • Cardiomyocyte Ca2+-handling
  • Signal transduction 
  • Energy metabolism 

Research affiliations

  • Principal investigator, Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre 
  • Director of development, St. Boniface Hospital Albrechtsen Research Centre 

Research groups

  • Division of Cardiovascular Sciences and Disease 
  • International Society for Heart Research
  • International Academy of Cardiovascular Sciences 

Research summary

Dr. Naranjan Dhalla has demonstrated that Ca2+-handling defects in cardiomyocytes and remodeling of subcellular organelles for contractile dysfunction in heart failure, diabetic cardiomyopathy and ischemic heart, occur due to alterations in gene expression as well as proteolytic activation. He has provided evidence that both oxidative stress and intracellular Ca2+-overload are major mechanisms for the development of ischemia–reperfusion injury. His work has revealed that cardiac dysfunction and lethal arrhythmias in stress-induced heart disease are consequence of the oxidation products of catecholamines. His research has formed the metabolic, subcellular and molecular basis and identified different targets for drug development for the therapy of heart disease.

Biography

Dr. Naranjan Dhalla is a distinguished professor in the physiology and pathophysiology department at UM’s Max Rady College of Medicine.

Following graduation and two years of working as assistant professor in the St. Louis University, he joined UM in 1968 where he progressed to the academic rank of full professor in 1974. He has been working in the field of experimental cardiology with a focus on pathophysiology, biochemistry, pharmacology and molecular biology of cardiac dysfunction.

He served for 19 years as founding director of the Institute of Cardiovascular Sciences at the St. Boniface Hospital in Winnipeg.

He developed the International Society for Heart Research for promoting cardiovascular research all over the world in his capacity as secretary general and then president during 1972-1996.

Since 1996, he has been serving the International Academy of Cardiovascular Sciences as executive director for promoting cardiovascular education and prevention of heart disease; he was elected as honorary life president in 2016.

For the past 35 years, he has been editor-in-chief of international journal Molecular and Cellular Biochemistry published by Springer, New York.

He has published 859 full length research papers and review articles, which are cited more than 31,886 times with h-index of 83. In addition, he has edited 64 books, and trained 166 scientists, post-doctoral fellows and graduate students in biochemical and molecular medicine. He has been invited to give over 535 talks at various conferences and institutions around the globe.

Education

He obtained his master of science degree from the University of Pennsylvania in 1963 and PhD from the University of Pittsburgh in 1965.

Awards

Dr. Dhalla has received 209 honours and awards, including six honourary doctorate degrees and four honoris causa professorships from different institutions. Below is a selection:

2015: Honorary Doctorate, University of Buenos Aires, Argentina

2014: Honorary Doctorate, University of Kragujevac, Serbia

2010: Honorary Doctor of Science, Guru Nanak Dev University, Amritsar

2009: Honorary Doctor of Science, Panjab University, Chandigarh

2005: Fellow Canadian Academy of Health Sciences

2002: Order of Manitoba

2000: Fellow of the Royal Society

1997: Honorary Doctor of Science, Slovak Academy of Science, Bratislava

1997: Member of the Order of Canada

1995: Honorary Doctor of Medicine, Charles University, Prague

1991: Distinguished Professor, University of Manitoba

Contact us

Physiology and Pathophysiology
432 Basic Medical Sciences Building
745 Bannatyne Avenue
University of Manitoba
Winnipeg, MB R3E 0J9 Canada

204-789-3696
204-789-3934