• Naranjan Dhalla headshot
  • Distinguished professor

    Max Rady College of Medicine
    Physiology and Pathophysiology
    University of Manitoba
    Institute of Cardiovascular Sciences
    St. Boniface Hospital Albrechtsen Research Centre 
    Winnipeg, Manitoba R2H 2A6

    Phone: 204-235-3417
    Fax: 204-237-0347


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Research summary

Dr. Naranjan Dhalla has demonstrated that Ca2+-handling defects in cardiomyocytes and remodeling of subcellular organelles for contractile dysfunction in heart failure, diabetic cardiomyopathy and ischemic heart, occur due to alterations in gene expression as well as proteolytic activation. He has provided evidence that both oxidative stress and intracellular Ca2+-overload are major mechanisms for the development of ischemia–reperfusion injury. His work has revealed that cardiac dysfunction and lethal arrhythmias in stress-induced heart disease are consequence of the oxidation products of catecholamines. His research has formed the metabolic, subcellular and molecular basis and identified different targets for drug development for the therapy of heart disease.


Dr. Naranjan Dhalla is a distinguished professor in the physiology and pathophysiology department at UM’s Max Rady College of Medicine. He obtained his master of science degree from the University of Pennsylvania in 1963 and PhD from the University of Pittsburgh in 1965. After two years of working as assistant professor in the St. Louis University, he joined UM in 1968 where he progressed to the academic rank of full professor in 1974. He served for 19 years as founding director of the Institute of Cardiovascular Sciences at the St. Boniface Hospital in Winnipeg.  He has been working in the field of experimental cardiology with a focus on pathophysiology, biochemistry, pharmacology and molecular biology of cardiac dysfunction. He has published 837 full length research papers and review articles, which are cited more than 30, 215 times with h-index of 80. In addition, he has edited 61 books, and trained 166 scientists, post-doctoral fellows and graduate students in biochemical and molecular medicine. Dr. Dhalla has received 205 honours and awards, including six honourary doctorate degrees and four honoris causa professorships from different Institutions. He has been invited to give over 530 talks at various conferences and institutions around the globe. In his capacity as secretary general and then president during 1972-1996, he developed the International Society for Heart Research for promoting cardiovascular research all over the world. Since 1996 he has been serving the International Academy of Cardiovascular Sciences as executive director for promoting cardiovascular education and prevention of heart disease; he was elected as honorary life president in 2016. For the past 34 years, he has been editor-in-chief of international journal Molecular and Cellular Biochemistry published by Springer, New York. 



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Physiology and Pathophysiology
432 Basic Medical Sciences Building
745 Bannatyne Avenue
University of Manitoba
Winnipeg, MB R3E 0J9 Canada