Meenu Sharma, BSc, MSc, PhD

Research achievements

Research themes

Comparison of repetitive sequence-based PCR for rapid genotyping and identification of non-tuberculosis mycobacteria

Determining virulence of Manitoba tuberculosis fingerprints in an animal model

How the immunogenetic program and socio-economic conditions of Manitoba's First Nations affect their response to mycobacterium isolates

MLST of non-tuberculous mycobacteria

Molecular markers of drug resistance in tuberculosis

Study immune responses in mice infected with mycobacterium tuberculosis strains

Study of human genetic polymorphisms (KIR) in cases with active and latent tuberculosis infection

Tuberculosis genotyping databases

Uncovering signatures of mycobacterium tuberculosis specific immune responses to distinguish active versus latent disease

Validation of first- and second-line antimicrobials against mycobacterium tuberculosis

Whole genome sequencing of mycobacterium tuberculosis and other mycobacterium species

Research interests

• Antibiotics and resistance in mycobacteriology
• Detection and identification of mycobacteria
• Reference and diagnostics of tuberculosis
• Tuberculosis in Canadian north
• Whole genome sequencing

Keywords

• Mouse model
• Mycobacterial susceptibility testing
• Mycobacterium abscessus MLST
• Mycobacterium tuberculosis
• Non-tuberculous mycobacteria
• Real time PCR methods
• Resistance mechanisms in mycobacteria
• tuberculosis genotyping
• Whole genome sequencing

Research affiliations

• Research scientist, National Reference Centre of Mycobacteriolog (NRCM)
• National Microbiology Laboratory (NML)
• Public Health Agency of Canada (PHAC), Government of Canada