Community Health Sciences, Rady Faculty of Health Sciences

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Research interests

Research affiliations

Research summary

Dr. Lyle McKinnon’s research interests include understanding the HIV transmission in human cohorts, and the mucosal immune bases of infectious disease protection and susceptibility.

His group focuses on understanding the epidemiology and biology of HIV transmission and acute infection in humans, particularly in the female genital and gastrointestinal tracts.

Studies include defining factors that influence the number and types of HIV target cells at various sites around the body, how the microbiome and host interact at the mucosal surface, and how immune regulation of inflammation may be key to enhancing mucosal barrier integrity.

This work is done in collaboration with female sex workers, men who have sex with men, and young women. The ultimate goal of this work is to enhance the growing number of available, effective HIV prevention options for those who need them most.


Dr. Lyle McKinnon is an associate professor in medical microbiology and infectious diseases as well as community health sciences at the University of Manitoba. He has cross appointments at CAPRISA and the University of Nairobi.

Dr. McKinnon did his PhD at the University of Manitoba focused on understanding HIV-specific CTL responses and HIV diversity. His postdoctoral work was carried out at the University of Toronto on defining mucosal HIV target cells in the female genital tract.

During his training he spent ~10 years in Nairobi, Kenya carrying out field research including epidemiological and immunological studies of high risk men and women. He then spent >3 years at CAPRISA in Durban, South Africa continuing his work in mucosal immunology in the context of HIV prevention trials in women.

He has published 91 peer-reviewed articles and has an H-index of 32, and has held funding from the Canadian Institutes of Health Research (CIHR), Canadian Foundation for Innovation (CFI), Bill & Melinda Gates Foundation, National Institutes of Health (NIH), Research Manitoba, Manitoba Medical Services Foundation, University of Manitoba Rady Faculty of Health Sciences, and others.



  • Immunologist of the month for January, (2019)
  • Finalist, Canadian Broadcasting Corporation (CBC) Manitoba's Future 40 (2018)
  • Merit Award in Research, Scholarly Work and Creative Activities, University of Manitoba / University of Manitoba Faculty Association. $3000. (2018)
  • The Ken Hughes Young Investigator Award for Medical Research, Rady Faculty of Health Sciences, University of Manitoba. $1900. (2018)
  • Dr. Frank Plummer Researcher of the Year Award, Department of Medical Microbiology and Infectious Diseases, University of Manitoba. $1000. (2017)
  • Canadian Foundation for AIDS Research (CANFAR) and the Canadian Association for HIV Researchers (CAHR) Excellence in Research Award, Basic Sciences track. (2017)
  • New Investigator Award, Canadian Institute of Health Research (CIHR),  $60,000/year for 5 years (2016-21)             

ORCID profile

Visit Lyle McKinnon’s Google Scholar profile for a complete listing.

Lyle McKinnon’s profile

Contact us

Medical Microbiology and Infectious Diseases
Max Rady College of Medicine
Room 543 - 745 Bannatyne Avenue
University of Manitoba (Bannatyne campus)
Winnipeg, MB R3E 0J9 Canada