Cross appointments
Holds cross appointments with:
Department of pharmacology and therapeutics, Max Rady College of Medicine
Research summary
A major focus of Dr. Kirshenbaum’s laboratory is directed toward understanding the molecular pathways that underlie sex specific difference in heart failure. Dr. Kirshenbaum is investigating mechanisms that regulate cellular quality control mechanisms in heart, a process known as “autophagy” with a focus on mitochondrial metabolism. Dr. Kirshenbaum’s major contributions include discovery of the Bcl-2 family protein Bnip3 and its role in the development of heart failure after heart attack.
Research themes
- Cardiovascular cell growth
- Programmed cell death
- Mitochondrial metabolism
Keywords
- Autophagy
- Cell death
- Heart failure
- Mitochondrial metabolism
Research interests
- Understanding the molecular pathways and genetic factors that underlie the mechanisms of cardiac growth control and heart cell death
- Sex-specific differences in heart failure
- Use of advanced techniques in molecular biology with a goal of informing or developing treatments for cardiovascular diseases
Research affiliations
Research affiliations include:
Professor, department of pharmacology and therapeutics, Max Rady College of Medicine, University of Manitoba
Director research development, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba
Director, Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre
Principal investigator, cardiac gene biology, Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre
Canada Research Chair in Molecular Cardiology