Max Rady College of Medicine
Physiology and Pathophysiology
Room 408 – Basic Medical Sciences Building
745 Bannatyne Avenue
University of Manitoba
Winnipeg, Manitoba R3E 0W2
Dr. James Nagy’s research program for over three decades has centered on gap junctions between cells in the CNS, and is currently focused on:
1) proteomic, molecular, biochemical and immunofluorescence imaging approaches to identify the multimolecular structural and regulatory protein composition of electrical synapses composed of connexin36, to determine the functions of those proteins, and to investigate intracellular signalling pathways and mechanisms that serve to regulate connexin assembly, degradation and turnover in gap junctions, and processes that regulate dynamic events of electrical synaptic transmission;
2) Identification of connexins expressed in neurons and related cells, delineation of sites where connexins form electrical synapses in mammalian neuronal circuitry and determination of the functional roles of those synapses in systems physiology.
Dr. Nagy is a full professor at UM.
He has over 200 peer-reviewed publications, and numerous book chapters and reviews, with 25 papers published in the last seven years.
His research has been supported by grants funding from NSERC, CIHR and NIH, and the impact is indicated by the >16,000 cumulative citations to his publications, with a resulting H-index of 73 (Google Scholar) achieved through a career-long commitment to venture into novel and challenging areas of neuroscience research.
His collaborative partnerships with industry over the last 25 years has resulted in the development of numerous high quality antibodies against CNS proteins, including widely used polyclonal and monoclonal antibodies against the family of 20 connexins.
Dr. Nagy obtained his bachelor of science and master of science in biochemistry and his PhD in interdisciplinary neuroscience at the University of British Columbia.
He then conducted three years of postdoctoral studies at the University of Cambridge, England and an additional six months at the University of Toronto.