• Portrait of Hani-El-Gabalawy
  • Professor

    Max Rady College of Medicine
    Internal Medicine
    University of Manitoba
    Room RR149 – 800 Sherbrook Street
    Winnipeg, Manitoba R3E 1M4

    Phone: 204-787-2208 (office)
    Fax: 204-787-2475 (office)
    Phone: 204-787-2392 (clinic)
    Fax: 204-787-4594 (clinic)
    hani.elgabalawy@umanitoba.ca

Cross-appointments

Immunology, Max Rady College of Medicine

Endowed Rheumatology Research Chair

Research summary

Dr. Hani El-Gabalawy has dedicated his research career to understanding the mechanisms initiating and sustaining rheumatoid arthritis (RA). He has authored the definitive chapter on RA synovial pathology in a top rheumatology textbook. Currently, Dr. El-Gabalawy's primary research interests lie in the autoimmune mechanisms preceding the onset of RA and how they can be modulated to reduce the risk of disease development and progression. He is particularly interested in the effects of immunomodulatory nutritional supplements in preventing the progression of RA autoimmunity.

Since 2004, his research program has assembled a unique longitudinal cohort of at-risk relatives of First Nations RA patients in Central Canada to study the mechanisms that promote the progression of autoimmunity towards the development of RA. This project has received uninterrupted funding from the Canadian Institutes of Health Research for the past 15 years. Dr. El-Gabalawy's collaborations around this project have spanned several academic centers across Canada, the US, and particularly at Leiden University in The Netherlands. It is hoped that these studies will provide valuable insights into how RA starts, and ultimately help provide the biological basis for preventative strategies.

  • Research themes

    Immunology

    Rheumatology

    Indigenous health

    Prevention

    Research affiliations and groups

    Department of rheumatology, Leiden University, The Netherlands

    Manitoba Centre for Proteomics and Systems Biology

  • Keywords

    Rheumatoid arthritis

    Autoimmunity

    Immunology

    Indigenous health

    Nutritional interventions

    Immunological biomarkers

    Preclinical autoimmunity

    Synovial fibroblasts

    Hypoxia

    Disease prevention

Biography

Dr. Hani El-Gabalawy is a physician and researcher, currently holding positions as a professor of medicine and immunology, and an endowed Rheumatology Research Chair at the University of Manitoba. He is widely recognized for his contributions in the field of rheumatology and immunology, with a specific focus on rheumatoid arthritis (RA) and Indigenous health.

Dr. El-Gabalawy completed his medical studies at the University of Calgary, where he earned his MD and Bachelor of Science degrees. He then completed his internal medicine training and rheumatology fellowship at McGill University. He later became a visiting scientist at the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) in Bethesda, Maryland, from 1997 to 2000, before returning to UM in 2000.

From 2013 until 2017, Dr El-Gabalawy served as the Scientific Director of the CIHR Institute of Musculoskeletal Health and Arthritis (IMHA) where he founded a number of important initiatives including the establishment and funding of a Canada/Netherlands network for childhood arthritis research (UCAN-CANDU). He now serves as the Chair of the integrated Scientific and Medical Advisory Committee (iSMAC) for the Arthritis Society Canada. 

Throughout his career, Dr. El-Gabalawy has focused his research on understanding the mechanisms that initiate and sustain RA. He has been instrumental in documenting the histopathology and immunohistology of rheumatoid synovitis, and in analyzing the role of hypoxia in activating synovial fibroblasts and mediating processes that sustain chronic synovitis. Dr. El-Gabalawy's extensive work in this area culminated in him authoring the definitive chapter on the topic in a top rheumatology textbook.

Currently, Dr. El-Gabalawy's research program focuses on autoimmune mechanisms preceding the onset of RA, and how they can be modulated to reduce the risk of disease development and progression. He has been leading a longitudinal cohort study of at-risk relatives of First Nations RA patients in Central Canada since 2004, which has received uninterrupted funding from the Canadian Institutes of Health Research for the past 15 years. His collaborations on this project have spanned several academic centers across Canada, the US, and particularly at Leiden University in The Netherlands. Dr. El-Gabalawy and his team are investigating the effects of immunomodulatory nutritional supplements in preventing the progression of RA autoimmunity.

Dr. El-Gabalawy has been recognized with numerous awards for his contributions to rheumatology and Indigenous health, including the Canadian Rheumatology Association Masters Award, the Master of the American College of Rheumatology, and the Canadian Rheumatology Association Distinguished Investigator Award. He has also been awarded a fellowship in the Canadian Academy of Health Sciences and is the recipient of the Queen Elizabeth II Diamond Jubilee Medal. Dr. El-Gabalawy's dedication to the field of rheumatology and Indigenous health has made him a highly respected and sought-after expert in his field.

In 2024, Dr El-Gabalawy has the honour of presenting the annual “Dunlop-Dottridge Lecture”, which is the premier state of the art lecture for the Canadian Rheumatology Association Annual Scientific Meeting.

Education

Bachelor of Science, University of Calgary (1974)

Doctor of Medicine (MD), University of Calgary (1977)

Fellow of The Royal College of Physicians of Canada (FRCPC), Internal Medicine (1983)

Fellow of The Royal College of Physicians of Canada (FRCPC), Rheumatology (1984)

Specialty Certificate Province of Quebec: Rheumatology (1984)

American Board of Internal Medicine: Rheumatology (1984)

Select awards

Outstanding Reviewer, Peer Review - Fall 2019 Project Grant Competition, Canadian Institutes of Health Research and the College of Reviewers (2020)

Canadian Rheumatology Association (Inaugural) Masters Award, Victoria, B.C. (2020)

Master of the American College of Rheumatology, Atlanta, Georgia (2019)

Canadian Rheumatology Association Distinguished Investigator Award, Quebec City (2015)

Queen Elizabeth II Diamond Jubilee Medal, Ottawa (2013)

Fellowship in the Canadian Academy of Health Sciences (CAHS), Ottawa (2010)

Endowed Rheumatology Research Chair (2003 to present)

 

Dr. Hani El-Gabalawy In the news

Contact us

Immunology
Max Rady College of Medicine
Apotex Centre
Room 471, 750 McDermot Avenue
University of Manitoba (Bannatyne campus)
Winnipeg, MB R3E 0T5 Canada

204-789-3509
204-789-3921
204-480-1347