• Christopher Pascoe
  • Assistant professor

    Max Rady College of Medicine
    Physiology and pathophysiology
    602 – John Buhler Research Centre
    715 McDermot Avenue
    University of Manitoba
    Winnipeg, MB, R3E 0W2

    Phone: 204-789-3345

Cross appointments

Does not hold any cross appointments.

Research summary

Chronic respiratory diseases, including asthma and chronic obstructive pulmonary disease (COPD), are significant health burdens in Canadians. Research shows that both genetic and environmental risk factors are important in the development of these conditions. Although treatments exist to manage the symptoms, individuals with chronic respiratory disease still suffer significant morbidity and mortality. Through an understanding of how the early life environment influences risk for chronic disease, it may be possible to develop strategies and treatments that reduce risk and prevent disease development.

Dr. Pascoe’s team uses animal and cell models, and human clinical samples to address two research focuses: 

  1. How lipid mediators regulate normal lung cellular physiology. These signaling molecules, known as oxylipins, are known to regulate a diverse set of cellular functions but their role in regulating lung physiology remains largely unexplored. Dr. Pascoe’s team uses cell based model of airway cells (airway smooth muscle, airway fibroblasts and airway epithelium) to explore both the types of oxylipins produced by cells and how these oxylipins regulate cellular physiology. By understanding what cellular processes these oxylipins influence in the lung, we can begin to understand the importance of these understudied molecules in the respiratory system. 
  2. How the environment influences the pathophysiology and developmental origins of chronic respiratory disease. The environment plays a key role in determining risk for and development of chronic respiratory diseases. Exposure to cigarette smoke, maternal diabetes and e-cigarettes are associated with deficits in lung health. Dr. Pascoe’s team uses animal and cell based models, along with clinical samples, to study how the environment changes cell function and lung health. His team measures changes in cellular transcriptomes, lipidomes, and proteomes to determine whether these changes relate to changes in lung function. His team focuses on whether exposure maternal smoking, maternal diabetes or e-cigarettes promote future lung disease.

Research theme

  • Pathophysiology and developmental origins of chronic airway disease

Research interests

  • Asthma
  • COPD
  • Airway smooth muscle
  • In utero exposure
  • Oxylipins
  • Amniotic fluid
  • Cigarette smoke
  • Maternal diabetes
  • E-cigarettes

Research groups

Research groups include:

  • Biology of Breathing Theme (BoB)
  • Canadian Respiratory Research Network

Research affiliation

  • Principal investigator, Children’s Hospital Research Institute of Manitoba (CHRIM)



Dr. Pascoe completed a bachelor of science in biology at the University of the Fraser Valley. He went on to earn his PhD in experimental medicine at the University of British Columbia, where his research focused on airway smooth muscle contractility in the context of asthma.

He conducted his postdoctoral training at the Children’s Hospital Research Institute of Manitoba at the University of Manitoba, where he began to focus more on cell and animal models of chronic respiratory disease. It was during his post-doctoral training that he developed his interest in the developmental origins of lung disease, securing funding from the DEVOTION Network to explore the relationship between maternal diabetes and offspring lung dysfunction.

In 2017, he received the prestigious Banting Postdoctoral Fellowship for his work on the developmental origins of lung disease using an animal model.

In late 2019, he joined the Rady Faculty of Health Sciences in the department of physiology and pathophysiology as an assistant professor and principal investigator in the Children’s Hospital Research Institute of Manitoba.


  • Postdoctoral fellowship, University of Manitoba (2019)
  • PhD (experimental medicine), University of Manitoba (2015)
  • Bachelor of science (biology), University of the Fraser Valley (2010)


  • Banting postdoctoral fellowship (2017)
  • CIHR postdoctoral fellowship (accepted in name) (2017)
  • Breathing As One Inspiration Post Award, The Lung Association (2017)
  • Stuart J. Hirst Award, ATS (2016)

Contact us

Physiology and Pathophysiology
432 Basic Medical Sciences Building
745 Bannatyne Avenue
University of Manitoba
Winnipeg, MB R3E 0J9 Canada