Brad Doble, PhD

  • icon book

    Canada Research Chair

  • Brad Doble headshot

  • Associate professor

    Max Rady College of Medicine
    Pediatrics and Child Health
    Room 615 – Basic Medical Sciences Building
    744 Bannatyne Avenue
    University of Manitoba
    Winnipeg, Manitoba R3E 0W2

    Phone: 204-202-3815
    brad.doble@umanitoba.ca

Cross-appointment

Biochemistry and Medical Genetics, Max Rady College of Medicine 

Research summary

The Doble Lab at the Max Rady College of Medicine is at the forefront of stem cell research, studying the mechanisms that regulate cell fate decisions in stem cells. Led by Dr. Brad Doble, an expert in the field with over a decade of experience, the lab has a particular focus on key developmental signaling pathways such as the Wnt pathway.

The lab has developed a wide range of expertise in methods aimed at understanding the mechanisms that regulate transcription, epigenetics, post-transcriptional events, post-translational modifications and protein-protein interactions. These methods have been used to uncover key insights into the mechanisms that underlie the genesis and progression of most cancers and developmental disorders.

Currently, the Doble Lab is actively engaged in several exciting research projects, including:

  • Studying stem cell models of some of the earliest cell fate changes that occur during embryonic development
  • Characterizing two cell lines derived from a genetic mouse model of Wnt subgroup medulloblastoma
  • Developing new models with which to study medulloblastoma and other pediatric diseases

The lab also has expertise in genome editing techniques such as TALENs and CRISPR/Cas, which are used to study genetic diseases.

The Doble Lab is not only making significant contributions to the field of stem cell biology, but also to the fields of cancer and developmental disorders research. 

  • Research interests

    Cellular differentiation in vitro

    Genetic and epigenetic mechanisms in health and disease

    Medulloblastoma

    Developmental disorders

    Research affiliation

    Research scientist, Children’s Hospital Research Institute of Manitoba (CHRIM)

  • Keywords

    • Cancer
    • Developmental disorders
    • Epigenetics
    • Epigenomics
    • Genetic diseases
    • Genome editing (TALENs, CRISPR/Cas)
    • GSK-3 signaling
    • Medulloblastoma
    • Micropatterning
    • Proteomics
    • Stem cells
    • Transcriptomics
    • Transcription
    • Wnt signaling

Biography

Dr. Brad Doble is an associate professor of pediatrics and child health and biochemistry and medical genetics at the Max Rady College of Medicine. He holds the prestigious Bihler Chair in Stem Cell Research, a testament to his groundbreaking work in the field of stem cell biology.

Dr. Doble received his PhD at the University of Manitoba, where he delved into the intricacies of cardiovascular cell biology under the guidance of renowned scientist Dr. Elissavet Kardami. His thesis focused on the role of gap junctions in cardiac cell homeostasis, laying the foundation for his future research in stem cell biology.

After completing his PhD, Dr. Doble moved on to postdoctoral studies at the prestigious Ontario Cancer Institute/Princess Margaret Hospital in Toronto. There, he worked under the mentorship of Dr. Jim Woodgett, gaining invaluable expertise in the genetic manipulation of mouse embryonic stem cells and the development of novel mouse models targeting the kinases GSK-3α and GSK-3β, which are involved in myriad cellular processes and are implicated in numerous human diseases including cancer, Alzheimer’s disease, and type II diabetes.

With over a decade of experience as a principal investigator at McMaster University, Dr. Doble returned to his alma mater, the University of Manitoba in July of 2019. He brings with him a wealth of knowledge and experience, and continues to make significant contributions to the field of stem cell biology through his cutting-edge research in the Doble Lab.

Education

  • PhD in physiology, University of Manitoba
  • Bachelor of science in genetics (honours) University of Manitoba

Awards

  • Bihler Chair in Stem Cell Biology (2019)
  • Canada Research Chair Tier II in Stem Cell Signaling (2007-2017)

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Contact us

Pediatrics and Child Health
CE-208 Children's Hospital, Health Sciences Centre
840 Sherbrook Street
University of Manitoba
Winnipeg, MB R3A 1S1 Canada

dyoung4@hsc.mb.ca
204-787-8020
204-787-4807