Frederick Zeiler, BSc, MD, PhD, CIP, FRCSC

Cross-appointments

  • Associate professor, human anatomy and cell science, Max Rady College of Medicine
  • Associate professor, core member, biomedical engineering, Price Faculty of Engineering
  • Research affiliate, Centre on Aging
  • Honorary visiting fellow, anaesthesia, department of medicine, Addenbrooke’s Hospital, University of Cambridge

Accepting graduate students

  • BSc (Med) - Yes
  • Master's - Yes (through HACS, BME and Surgery)
  • PhD - Yes (through HACS and BME)
  • Postdoc - Yes

Research themes 

  • Cranial neurotrauma
  • Biomedical engineering
  • Advanced bio-signal analytics
  • Time-series methodologies
  • Big data approaches
  • Integrated omics

Research interests 

  • Cerebrovascular reactivity monitoring
  • Compensatory reserve monitoring
  • Personalized medicine in neurotrauma
  • Novel instrument development
  • Application of machine learning to cerebral physiologic data
  • Complex ‘omics’ integration

Research affiliations

  • Rudy Falk Clinician-Scientist Professor, University of Manitoba
  • Director and principal investigator, Winnipeg Acute TBI Laboratory, University of Manitoba
  • Research affiliate, Centre on Aging, University of Manitoba
  • Director of research – neurosurgery, University of Manitoba
  • Honorary visiting fellow, University of Cambridge
  • Chair, Canadian High Resolution TBI (CAHR-TBI) Research Collaborative
  • Scientist, Canadian Traumatic Brain Injury Research Consortium (CTRC)
  • Participant and investigator, Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI) Study

Research summary

Dr. Zeiler leads the Winnipeg Acute TBI Laboratories at Health Sciences Centre in Winnipeg. His research program is focused on the application of multi-modal invasive/non-invasive cranial physiologic monitoring for the continuous assessment of cerebral autoregulation, compensatory reserve, autonomics and signal entropy. This program integrates complex high-frequency signal processing, with neuroimaging, serum/CSF/microdialysis protein and genetic biomarkers. The goal is to uncover the molecular mechanisms involved in impaired cerebrovascular reactivity in TBI, leading to the development of potential therapeutic targets directed at prevention and treatment of vascular dysfunction in TBI. This program maintains strong ongoing collaborative ties with many international centers including: University of Cambridge, Karolinska Institute, University of Helsinki and Maastricht University. His lab is funded through a variety of local, national and international sources, including: the Manitoba Public Insurance (MPI) Neuroscience Research Endowment/Operating Fund, Canadian Institutes of Health Research, Canada Foundation for Innovation, Swedish Brain Fund and the National Institutes of Health.

Biography

Frederick Zeiler is a Canadian neurosurgeon who was hired as a clinician-scientist at UM in 2019. He completed his bachelor of science degree at UM, focused on applied mathematics and physical chemistry, holding Natural Sciences and Engineering Research Council (NSERC) summer research awards during this time. He went on to complete his medical school at UM, followed by his neurosurgery residency at the same institution, receiving certification in neurosurgery from the Royal College of Surgeons of Canada. Dr. Zeiler has also completed dedicated fellowship training in both neurocritical care at the Montreal Neurological Institute, and the Royal College of Physicians and Surgeons of Canada (RCPSC) clinician investigator program at UM. Finally, he completed his PhD training at the University of Cambridge, with his studies focused on advanced multi-modal monitoring of cerebrovascular reactivity in adult moderate and severe traumatic brain injury (TBI), under the supervision of world experts in TBI research: professors David Menon and Marek Czosnyka. During his time in Cambridge, he was recognized as both a Royal College of Surgeons of Canada Travelling Fellow in Surgery and University of Cambridge International Trust Scholar for the entirety of his studies.
 
Dr. Zeiler is the author of over 250 peer-reviewed manuscripts, abstracts and textbook chapter publications, and recipient of numerous awards for academic accomplishments. Currently, Dr. Zeiler is an associate professor and director of neurosurgery research, while recently being awarded the Rudy Falk Clinician-Scientist Professorship at UM and holding the position of Honorary Visiting Fellow at the University of Cambridge. He runs the Winnipeg Acute TBI Laboratories at UM, while his clinical practice focuses on peri-operative care of critically ill neurotrauma patients. 

Education

  • PhD (cerebrovascular physiology in TBI), University of Cambridge 
  • Certification (clinician-investigator), Royal College of Physicians and Surgeons of Canada
  • Fellowship (clinician-investigator), University of Manitoba 
  • Certification/Fellowship (neurosurgery), Royal College of Physicians and Surgeons of Canada
  • Fellowship (neurocritical care), Montreal Neurological Institute, McGill 
  • Residency (neurosurgery), University of Manitoba
  • Medical Doctorate, University of Manitoba
  • Primary Care Paramedic, CritCare Paramedic Academy
  • Bachelor of Science, University of Manitoba

Awards

  • Falconer Rh Award, Winnipeg Rh Institute Foundation, University of Manitoba (2020)
  • Centre on Aging Fellowship, University of Manitoba (2020)
  • Rudy Falk Clinician-Scientist Professorship, University of Manitoba (2019 – Present)
  • Cambridge International Trust Scholar, University of Cambridge (2016-2019)
  • Harry S. Morton Travelling Fellow in Surgery, Royal College of Physicians and Surgeons of Canada (2016-17; 2017-18)
  • R. Samuel McLaughlin Fellowship, Manitoba Medical Service Foundation/University of Manitoba (2016)

ORCID profile

Visit Frederick Zeiler's ORCID profile for a complete listing.

Frederick Zeiler's profile

Contact us

Surgery
Max Rady College of Medicine
AE101-820 Sherbrook Street
University of Manitoba (Bannatyne campus)
Winnipeg, MB R3A 1R9 Canada

204-787-4587
204-787-1485
204-787-4884