• Associate professor, human anatomy and cell science, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba
  • Associate professor, core member, biomedical engineering, Faculty of Engineering, University of Manitoba
  • Research affiliate, Centre on Aging, University of Manitoba
  • Honorary visiting fellow, anaesthesia, Department of Medicine, Addenbrooke's Hospital, University of Cambridge

Dr. Zeiler leads the Winnipeg Acute Traumatic Brain Injury Laboratories at Health Sciences Centre in Winnipeg. His research program is focused on the application of multi-modal invasive and non-invasive cranial physiological monitoring for the continuous assessment of cerebral autoregulation, compensatory reserve, autonomics, and signal entropy. This program integrates complex high-frequency signal processing, with neuroimaging, serum, cerebrospinal fluid, microdialysis protein, and genetic biomarkers. The goal is to uncover the molecular mechanisms involved in impaired cerebrovascular reactivity in traumatic brain injury, leading to the development of potential therapeutic targets directed at prevention and treatment of vascular dysfunction in traumatic brain injury. This program maintains strong ongoing collaborative ties with many international centres including: University of Cambridge, Karolinska Institute, University of Helsinki, and Maastricht University. His lab is funded through a variety of local, national, and international sources, including: the Canada Foundation for Innovation, Canadian Institutes of Health Research, Manitoba Public Insurance Neuroscience Research Endowment and Operating Fund, National Institutes of Health, and Swedish Brain Fund.

Research themes

  • Advanced bio-signal analytics
  • Big data approaches
  • Biomedical engineering
  • Cranial neurotrauma
  • Integrated omics
  • Time-series methodologies

Research interests

  • Application of machine learning to cerebral physiological data
  • Cerebrovascular reactivity monitoring
  • Complex 'omics' integration
  • Compensatory reserve monitoring
  • Novel instrument development
  • Personalized medicine in neurotrauma

Research affiliations

  • Chair, Canadian High Resolution Traumatic Brain Injury Research Collaborative
  • Director and principal investigator, Winnipeg Acute Traumatic Brain Injury Laboratory, University of Manitoba
  • Director of research – neurosurgery, University of Manitoba
  • Honorary visiting fellow, University of Cambridge
  • Participant and investigator, Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury Study
  • Research affiliate, Centre on Aging, University of Manitoba
  • Rudy Falk Clinician-Scientist Professor, University of Manitoba
  • Scientist, Canadian Traumatic Brain Injury Research Consortium


Dr. Frederick Zeiler is a highly accomplished Canadian neurosurgeon who was hired as a clinician-scientist at the University of Manitoba (UM) in 2019. He has a wealth of experience and expertise in various areas of neurosurgery and has received numerous awards for his academic accomplishments.

Dr. Zeiler completed his undergraduate education at UM, where he earned a Bachelor of Science degree focused on applied mathematics and physical chemistry. During this time, he also received Natural Sciences and Engineering Research Council (NSERC) summer research awards. He then went on to complete his medical school and neurosurgery residency at UM, and received certification in neurosurgery from the Royal College of Surgeons of Canada. He has also completed dedicated fellowship training in both neurocritical care at the Montreal Neurological Institute, and the Royal College of Physicians and Surgeons of Canada (RCPSC) clinician investigator program at UM. Additionally, he completed his PhD training at the University of Cambridge, where he focused on advanced multi-modal monitoring of cerebrovascular reactivity in adult moderate and severe traumatic brain injury (TBI) under the supervision of world experts in TBI research, Professors David Menon and Marek Czosnyka. During his time in Cambridge, he was recognized as both a Royal College of Surgeons of Canada Travelling Fellow in Surgery and University of Cambridge International Trust Scholar.

Dr. Zeiler is the author of over 250 peer-reviewed manuscripts, abstracts, and textbook chapter publications. Currently, he is an associate professor and director of neurosurgery research at UM and holds the position of Honorary Visiting Fellow at the University of Cambridge. He also runs the Winnipeg Acute TBI Laboratories at UM and his clinical practice focuses on peri-operative care of critically ill neurotrauma patients. He was recently awarded the Rudy Falk Clinician-Scientist Professorship at UM.

  • Education

    PhD (cerebrovascular psychiatry in TBI), University of Cambridge

    Certification (clinician-investigator), Royal College of Physicians and Surgeons of Canada

    Fellowship (clinician-investigator), University of Manitoba

    Certification/Fellowship (neurosurgery), Royal College of Physicians and Surgeons of Canada

    Fellowship (neurocritical care), Montreal Neurological Institute, McGill

    Residency (neurosurgery), University of Manitoba

    Medical Doctorate, University of Manitoba

    Primary Care Paramedic, CritCare Paramedic Academy

    Bachelor of Science, University of Manitoba


  • Awards

    Falconer Rh Award, Winnipeg Rh Institute Foundation, University of Manitoba (2020)

    Centre on Aging Fellowship, University of Manitoba (2020)

    Rudy Falk Clinician-Scientist Professorship, University of Manitoba (2019 – Present)

    Cambridge International Trust Scholar, University of Cambridge (2016-2019)

    Harry S. Morton Travelling Fellow in Surgery, Royal College of Physicians and Surgeons of Canada (2016-17; 2017-18)

    R. Samuel McLaughlin Fellowship, Manitoba Medical Service Foundation/University of Manitoba (2016)

Contact us

Max Rady College of Medicine
AE101-820 Sherbrook Street
University of Manitoba (Bannatyne campus)
Winnipeg, MB R3A 1R9 Canada