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Research summary

Dr. Shyamala Dakshinamurti's group studies circulatory transition – the process of a baby coming off of mom's life support system and getting oxygen from inhaled air. Lung blood vessels have to dilate rapidly, in response to oxygen. In babies who don't get enough oxygen during birth, this complex transition can go very wrong, triggering the disease persistent pulmonary hypertension of the newborn (PPHN).

Dr. Dakshinamurti's research is on pulmonary hemodynamics in hypoxic conditions; and the physiology and pharmacology of vascular smooth muscle, specifically oxidative stress, prostanoid receptors and the enzyme adenylyl cyclase in hypoxic pulmonary arteries. Her team uses animal models, isolated blood vessels and cultured cells.


Dr. Shyamala Dakshinamurti is a neonatologist and biomedical researcher, heading the Neonatal Pulmonary Biology Lab and anchoring the small animal hemodynamics lab in the Children’s Hospital Research Institute of Manitoba (CHRIM).

Dr. Dakshinamurti is research director and scholarly oversight committee chair for the University of Manitoba’s Neonatology Fellowship Program. She served three consecutive terms on the Board of Directors of CHRIM, serves on the executive of CHRIM’s Biology of Breathing research theme, is on the board of the Winnipeg Rh Institute Foundation and the Manitoba Medical Services Foundation and is a member of the Manitoba Chemosensory Biology Research Group.

Dr. Dakshinamurti has an interest in scientific communication and is an alumna of the Alan Alda Center for Communicating Science summer institute (Stony Brook University, New York). She is on the organizing committee of the Canadian National Perinatal Research Meeting and chaired that meeting in 2018 and 2020. Since 2005, she has organized the annual Bowman Symposium on Neonatal Research in Winnipeg.



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Pediatrics and Child Health
CE-208 Children's Hospital, Health Sciences Centre
840 Sherbrook Street
University of Manitoba
Winnipeg, MB R3A 1S1 Canada