Yoav Keynan, MD, PhD

  • Portrait of Yoav Keynan.

  • Head, Section of Infectious Diseases
    Associate professor

    Max Rady College of Medicine
    Internal Medicine
    Room 507, Basic Medical Sciences Building
    745 Bannatyne Avenue
    University of Manitoba
    Winnipeg, Manitoba R3E 0J9

    Phone: 204-480-1317
    Phone: 204-977-5681 (assistant)
    Fax: 204-789-3926
    yaov.keynan@umanitoba.ca

Cross-appointments

  • Medical Microbiology and Infectious Diseases, Max Rady College of Medicine
  • Community Health Sciences, Max Rady College of Medicine

    Research summary

    His research focuses on immune and genetic determinants of immune activation and the role they play in HIV acquisition, progression and end-organ dysfunction. The laboratory is using a multidisciplinary approach to the study of pulmonary infections among HIV infected individuals, combining epidemiology, clinical aspects as well as study of the microbiome and the interaction with host immune responses. Additional area of research revolves around early markers of tuberculosis acquisition and determinants of susceptibility. The projects rely on local and international cohorts with growing collaboration and exchange in Medellin, Colombia.

    Research focus and interests

    • Innate and adaptive (T and B cell) immune responses to influenza infection and vaccination with emphasis on factors associated with Influenza cross-protection and disease severity
    • HIV disease progression. Study of the immunogenetic determinants and the effect of anti-inflammatory interventions on immune reconstitution
    • Tuberculosis: Host gene expression and cytokine profile used to identify latent TB infection and the transition to active disease
    • Clinical management of infectious diseases, pyogenic liver abscess caused by hypermucoviscous klebsiella; HIV care and management of opportunistic infections. POC detection of HIV status.

    Research affiliations

    Keywords

    • Antibody response
    • CD8 response
    • Flowcytometry
    • HIV immunology
    • Influenza
    • Suspension bead array

    Biography

    Dr. Keynan is an associate professor, departments of internal medicine, medical microbiology and infectious diseases, and community health sciences, and Ad Honorem professor at Universidad Pontificia Bolivariana in Medellin, Colombia. He is a clinician-scientist, infectious diseases consultant in the Winnipeg Regional Health Authority and the Manitoba HIV Program. He is the scientific director of the National Collaborating Centre for Infectious Diseases (NCCID) at the University of Manitoba focusing on infectious diseases knowledge translation for vulnerable populations.

    Education

    • PhD, Infectious Diseases/Medical Microbiology-Viral Immunology, completed in Dr. Keith Fowke’s Laboratory (2014)
    • Certified specialty in Internal Medicine (2004)
    • Residency, Division of Medicine, Carmel Medical Center, Haifa, Israel (2004)
    • Completion of residency license examinations, with honours (2003)
    • Internship, Meir Medical Center, Kfar-Saba, Israel (1995)
    • Doctor of Medicine, Faculty of Health Sciences, Ben-Gurion University of the Negev, Israel (1994); Dean’s list 1991, 1992, 1993
    • Albert Einstein College of Medicine, Bronx, NY, Pediatric Neurology, Honor (1992)
    • Albert Einstein College of Medicine, Bronx, NY, Rheumatology – elective (1992)

    Select awards

    • Doctors Manitoba, Scholastic Award (2020)
    • Manitoba Medical Students' Association (MMSA) teaching awards-Med II Best teaching in small group setting (2020)
    • Canadian Foundation for Infectious Diseases/ AMMI, Dr. John M. Embil Mentorship Award in Infectious Diseases (2019)
    • Faculty Educator of the Year Award, Department of Medical Microbiology and Infectious Diseases (2017)
    • Dr. Ethan Rubinstein Memorial Clinician Scientist Award, Department of Medical Microbiology and Infectious Diseases (2015)
    • Excellence in Teaching Award, Department of Internal Medicine, University of Manitoba (2013)

    Contact us

    Internal Medicine
    Room GC430, Health Sciences Centre
    820 Sherbrook Street
    University of Manitoba
    Winnipeg, MB R3A 1R9 Canada

    intmed@umanitoba.ca
    204-787-7772
    204-787-4826