Tanveer Sharif, PhD

  • Portrait of Tanveer Sharif.

  • Assistant professor 
    Canadian Cancer Society Emerging Scholar

    Max Rady College of Medicine
    Pathology
    Room 400 - 727 McDermot Avenue
    University of Manitoba
    Winnipeg, Manitoba R3E 3P5

    Phone: 204-789-3460
    tanveer.sharif@umanitoba.ca

Accepting graduate students

  • Master’s - Yes
  • PhD - Yes

Research themes

  • Molecular cancer biology
  • Precision medicine

Research interests

  • Regulation of metabolic rewiring and metabolic plasticity within heterogeneous brain tumor populations
  • Metabolic regulation of tumor suppressors and oncogenes
  • Metabolism-mediated modulation of post-translational modifications and epigenetics

Keywords

  • Brain tumors
  • Metabolism
  • Medulloblastoma
  • Glioblastoma
  • Tumor heterogeneity
  • Autophagy
  • Epigenetics

Research summary

Dr.  Tanveer Sharif’s current research is focused on identifying and characterizing new metabolism-based precision medicine therapeutic strategies for treating aggressive brain tumors. His work focuses on the two most common types of brain cancers in children and adults, medulloblastoma (MB) and glioblastoma (GBM). Using relevant cell and animal models as well as patient-derived brain tumor samples, Dr. Sharif’s research takes an in-depth approach to investigate the molecular mechanisms that mediate metabolic vulnerabilities and tumor heterogeneity to identify new therapeutic targets to improve patient responses and outcomes. 

Biography

Dr. Tanveer Sharif is a pharmacist turned researcher, he received his BSc in Pharmacy and MSc in Pharmacology. Dr. Sharif completed his PhD at the University of Strasbourg in France before moving to Canada in 2013 to pursue his postdoctoral fellowship at Dalhousie University, where he trained under the supervision of Dr. Patrick W.K. Lee prior to his retirement.

At Dalhousie, Dr. Sharif studied the role of tumor suppressors and metabolism in embryonal carcinoma stem cells and patient-derived brain tumor-initiating cells. In 2019, Dr. Sharif joined UM as a principal investigator to lead a new tumor suppressor biology, autophagy and Mmtabolism program in the department of pathology.

Education

  • Postdoctoral fellowship, Dalhousie University (2013-2019)
  • PhD (pharmacology), Université de Strasbourg (2012)
  • M.Sc. (pharmacology), Bahauddin Zakariya University (2006)
  • B.Sc. (pharmacy), Bahauddin Zakariya University (2004)

Awards

  • Grant award, Canadian Institute of Health Research (2022-2027, $956,250)
  • John R. Evans Leaders Fund grant, Canadian Foundation for Innovation & University of Manitoba (2022, $821,862)
  • Discovery Launch Supplement grant, Natural Sciences and Engineering Council of Canada (2021-22, $125,000)
  • Discovery grant, Natural Sciences and Engineering Council of Canada (2021-2026, $150,000)
  • Grant award, Canadian Cancer Society (2021-2026, $600,000)
  • Grant award, Cancer Research Society (2021-2023, $120,000)
  • Grant award, Health Sciences Centre Foundation (2020-2022, $70,000)
  • Grant award, Manitoba Medical Service Foundation and Cancer Care Manitoba Foundation (2021, $31,000)

ORCID profile

Visit Tanveer Sharif's ORCID profile for a complete listing.

Tanveer Sharif's profile

Contact us

Pathology
Max Rady College of Medicine
401 Brodie, 727 McDermot Avenue
University of Manitoba (Bannatyne campus)
Winnipeg, MB R3E 3P5 Canada

pathology@umanitoba.ca
204-789-3212
204-789-3931