• Portrait of Paul Marcogliese.
  • Assistant professor

    Max Rady College of Medicine
    Biochemistry and Medical Genetics
    Room 324 – 745 Bannatyne Avenue
    University of Manitoba
    Winnipeg, Manitoba R3E 0J9

    paul.marcogliese@umanitoba.ca

Keywords

  • Disease models
  • Drosophila
  • Functional genomics
  • Genetics
  • Molecular biology
  • Movement disorders
  • Neurobiology
  • Neurodegeneration
  • Neurodevelopment
  • Parkinson’s disease
  • Rare disease

Research affiliations

Research groups

  • CHRIM - Canadian Prairie Metabolic Network (CPMN)

Research summary

I am interested in the molecular and cellular mechanisms underlying neurological disease. While the etiology of diseases like Autism Spectrum Disorder (ASD) and Parkinson’s disease is complex, the study and identification genes responsible for rare disorders can offer insight into more common conditions. We primarily use a range of techniques in Drosophila melanogaster (fruit flies) to assess the functional consequences of the patient variants in vivo. Additionally, rapid generation of Drosophila with strong loss of function alleles in these genes provides a phenotyping and screening platform for unravelling biological mechanisms and drug testing.

Biography

Dr. Marcogliese joined the University of Manitoba as an assistant professor of biochemistry and medical genetics within the Rady Faculty of Health Sciences  in June 2022. 

During his PhD under the supervision of Dr. David Park, he studied cell, mouse, and fly models of Parkinson’s disease. He completed postdoctoral training at the Baylor College of Medicine, in Houston, Texas in the department of human and molecular genetics under the supervision of Dr. Hugo Bellen.

His research has helped identify novel human disease genes as well as implicate excess Wnt signalling in neurodegeneration.

Education

  • Cellular and Molecular Neuroscience PhD, University of Ottawa (2016)
  • Bachelor of Science (Honours) Integrated Science, Carleton University (2010)
  • Bachelor of Arts (Honours) Criminology, Carleton University (2006)

Awards

  • Postdoctoral Fellowship - Canadian Institutes for Health Research (2019)
  • Basic Research Fellowship – Parkinson Canada (2018 – declined)

Contact us

Biochemistry and Medical Genetics
Room 336 Basic Medical Sciences Building
745 Bannatyne Avenue
University of Manitoba
Winnipeg, MB R3E 0J9 Canada