Cross-appointments

Immunology, Max Rady College of Medicine

Accepting graduate students

Master's – Yes

PhD – Yes

Research themes

  • Regulation of chronic inflammation; focus on asthma and arthritis
  • Immune functions of host defence peptides
  • Development of peptide-based immunomodulatory therapeutics
  • Biological sex-related differences in airway inflammation and asthma

Research interest

  • Cytokines and Host Defence Peptides: Mechanisms in regulation of inflammation
  • Regulation of airway inflammation and hyperresponsiveness by synthetic innate defence regulator (IDR) peptides
  • Mechanisms of sex-related differences in asthma
  • Effect of inhaled air pollution on the lung and plasma proteins
  • Regulation of inflammatory arthritis by synthetic IDR peptides and other small molecules

Keywords

  • Innate immunity
  • Host defence peptides
  • Inflammation
  • Immunomodulation
  • Asthma
  • Inflammatory arthritis
  • Proteomics

Research affiliations

  • Biology of Breathing Research Group (CHRIM)
  • NanoMedicines Innovation Network
  • The Canadian Respiratory Research Network
  • The Canadian Glycomics Network, GlycoNet
  • The AllerGen Network (National Centres of Excellence)

Research groups

Research scientist, Children’s Hospital Research Institute of Manitoba (CHRIM)

Research summary

Dr. Neeloffer Mookherjee’s research program focuses on the regulation of inflammation in chronic diseases such as arthritis and asthma. Her research is at the forefront of defining immunity-related functions of molecules known as host defense peptides.

Dr. Mookherjee also studies aspects of how environmental exposures such as air pollution impact chronic disease. As the current Canadian Institutes of Health Research (CIHR) Chair in Sex and Gender Science in Respiratory Health, she is integrating the fundamentals of sex- and gender-based analyses in her work. Drug discovery projects in her group aim to develop small peptide-based immunomodulatory therapies for chronic disease such as severe asthma.

Biography

Dr. Neeloffer Mookherjee obtained her Doctor of Philosophy (PhD) in microbiology (2001) from the University of Victoria, and subsequently completed her postdoctoral fellowships at the Vaccine and Infectious Disease Organization (VIDO), and the University of British Columbia. Dr. Mookherjee joined the University of Manitoba as a faculty member within the department of internal medicine, section of proteomics in 2008.

Dr. Mookherjee’s research program provides access to expertise in immunology, cell biology, biochemistry, mass spectrometry and bioinformatics, which is perfectly suited to provide a strong foundation of knowledge for undergraduate and graduate students, and postdoctoral training. Her trainees are also integrated within the department of immunology, and the Biology of Breathing Research Group in CHRIM. These diverse research environments allow her trainees to directly interact with highly skilled personnel at different stages of their careers in both basic and clinical science. Dr. Mookherjee’s research group is an inclusive environment, committed to equity, diversity and inclusion.

Dr. Mookherjee is the Canadian Institutes of Health Research (CIHR) Sex and Gender Science Chair in Respiratory Health. Her research program integrates Sex and Gender Based Analyses (SGBA), primarily sex as a biological variable, in the regulation of inflammation and response to therapy in the lungs.

Dr. Mookherjee is a strong advocate for women in science, and is the current Chair of WISDOM (Women In Science: Development, Outreach and Mentorship) initiative at the Rady Faculty of Health Sciences. As a leader in WISDOM she has made valuable contributions that are helping to mitigate some of the barriers that are impeding the participation of women in academic and professional leadership positions. She is recognized for her excellence and distinction in mentoring academic women in science.

Education

  • Postdoctoral Training, University of British Columbia, BC, Canada
  • Postdoctoral Fellow, Vaccine and Infectious Disease Organization, Sask., Canada
  • PhD, University of Victoria, B.C., Canada (2001)
  • Master of Science, University of Bombay, India (1993)
  • Bachelor of Science, University of Bombay, India (1989)

Awards

  • Canadian Institutes of Health Research (CIHR) Sex and Gender Science Chair in Circulatory and Respiratory Health (2020)
  • The Ed Kroeger Mentorship Award, In recognition of Excellence and Distinction in Mentorship, Teaching and Research, provided by the Health Sciences Graduate Student Association, The University of Manitoba (2019)
  • Michelle Harkness Mentorship Award – Mentorship Development Grant ($4,500), The Allergy, Genes & Environment (AllerGen) National Network (2019)
  • Teaching Awards, department of immunology, University of Manitoba, (2014-2015, 2012-2013)

ORCID profile

Visit Neeloffer Mookherjee's ORCID profile or Google Scholar page for a complete listing.

Neeloffer Mookherjee profile

Contact us

Postgraduate Medical Education (PGME)
Max Rady College of Medicine
260 Brodie Centre, 727 McDermot Avenue
University of Manitoba (Bannatyne campus)
Winnipeg, MB R3E 3P5 Canada

204-789-3290
204-789-3929

Immunology
Max Rady College of Medicine
Apotex Centre
Room 471, 750 McDermot Avenue
University of Manitoba (Bannatyne campus)
Winnipeg, MB R3E 0T5 Canada

204-789-3509
204-789-3921
204-480-1347