Dr. Henry A. Dunn is an assistant professor in the Department of Pharmacology and Therapeutics at the University of Manitoba, and a principal investigator at St. Boniface Hospital Albrechtsen Research Centre where he leads the Molecular Pharmacology and Neuropsychiatric Disease Lab.
Dr. Dunn is best known for his work on G protein-coupled receptors (GPCRs): particularly, delineating molecular mechanisms of stress-induced anxiety and depression, and illuminating a novel trans-synaptic pharmacological regulation mechanism with relevance to attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and epilepsy.
These seminal studies have led to a keen interest in the interplay between synaptic adhesion molecules and synaptic GPCRs, including: (1) how these relationships are utilized in synaptic connectivity, neurotransmission and intracellular signalling, and (2) how these interfaces can be exploited for novel drug design in neuropsychiatric disease.