Max Rady College of Medicine
Pharmacology and Therapeutics
St. Boniface Hospital Research
Room R4050, 351 Tache Avenue
Winnipeg, Manitoba R2H 2A6
Principal Investigator, St. Boniface Hospital Research
Dr. Benedict Albensi’s laboratory is focused on understanding the biological basis of memory and what happens to memory when it is impaired. Much of the lab’s work is centered on the signaling pathway involving the transcription factor, nuclear factor kappa B (NF-kB), which is central to inflammatory processes and immune system function and also plays a central role in basic mechanisms of memory formation and recall. Over the last few years, Dr. Albensi’s work has largely focused on mitochondrial dysfunction in Alzheimer’s disease (AD). Recently, the Albensi lab has shown very early deficits and sex-based differences in mitochondrial function before the appearance of plaques and tangles, the classic hallmarks of AD.
Dr. Benedict Albensi is a professor of pharmacology and therapeutics and a principal investigator and the Everett Endowment Fund Chair for Alzheimer’s Research at the St. Boniface Hospital Research Centre. He is best known for his work with factors involved in aging, cognition, and Alzheimer’s disease (AD), such as nuclear factor kappa B (NF-kB), a mediator of inflammation and a required molecule for memory. He was awarded a postdoctoral fellowship at Georgetown University in Washington, DC, working with Drs. Faden and Pekar, where he developed MRI methods for investigating head trauma and cognition. He then went on to work as a postdoctoral scholar with Dr. Mark Mattson, an internationally recognized leader in neurodegenerative research, at the Sanders-Brown Center on Aging – University of Kentucky where he was the first to show NF-kB is required for synaptic plasticity in mammals. Other appointments have included the Cleveland Clinic, NPS Pharmaceuticals, Pfizer and Case Western Reserve University.