• Portrait of Donald Miller
  • Professor

    Max Rady College of Medicine
    Pharmacology and Therapeutics
    Room SR438, KIAM - Health Sciences Centre
    710 William Avenue
    Winnipeg, Manitoba R3E 3J7

    Phone: 204-789-3278
    donald.miller@umanitoba.ca

Accepting graduate students

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Research summary

Dr. Donald Miller’s research interests focus on understanding the cellular factors that control blood-brain barrier (BBB) permeability under both normal and pathophysiological conditions. Utilizing both cell culture and whole animal models, my laboratory examines various transport processes for moving drugs and solutes into and out of the brain. His research program includes examination of BBB changes during brain tumour development and identification of methods for increasing the delivery of chemotherapeutic agents to more effectively treat brain tumours; identification and characterization of drug efflux transport proteins in the blood-brain barrier and the molecular mechanisms influencing their activity and expression; and the design and development of nanoparticle drug delivery platforms for treating CNS diseases. His laboratory has also examined inflammatory processes including cytokine and lipid mediators of inflammation and their impact on brain endothelial response and has recently expanded into inflammatory cascades in other organ/tissues including chondrocytes (joint related inflammation) and microglia/macrophage (CNS and systemic inflammation).

Biography

Dr. Donald Miller is a professor in pharmacology and therapeutics at the University of Manitoba.

He is an internationally recognized expert in drug transporters and blood-brain barrier function, having served on grant and fellowship review panels at both the National Institutes of Health and Canadian Institutes of Health Research, as well as reviewer and site visit examiner for Austrian and European Union based program grant initiatives.

He has participated on external scientific advisory boards for Vireo Systems Inc. (US-based nutraceutical company) and SFB35 –Transporters in Health and Disease – a multiple researcher project scheme type grant from the University of Vienna.

His research interests include understanding cellular and molecular mechanisms regulating blood-brain barrier function under normal and pathological conditions and identification of methods for enhancing drug delivery to the brain.

Education

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ResearchGate profile

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Donald Miller's profile

Contact us

Pharmacology and Therapeutics
Max Rady College of Medicine
A205 Chown Bldg., 753 McDermot Avenue
University of Manitoba (Bannatyne campus)
Winnipeg, MB R3E 0T6 Canada

204-789-3553