Dr. Kirk McManus is a professor of biochemistry and medical genetics within the Rady Faculty of Health Sciences. He is also a senior scientist within the CancerCare Manitoba Research Institute at CancerCare Manitoba.
Dr. McManus received his bachelor of science in 1995 and master of science in 1999 from the University of Manitoba. In 1999, he moved to Edmonton, Alberta, to conduct his PhD studies in experimental oncology at the University of Alberta. He performed his post-doctoral work in molecular oncology at the Michael Smith Laboratories at the University of British Columbia and was subsequently recruited to CancerCare Manitoba and the University of Manitoba in June 2009.
His research interests are focused on identifying and characterizing the genes, proteins and pathways regulating chromosome stability in various cancer contexts and exploiting these defects to uncover novel therapeutic targets. He currently employs leading-edge genetics (RNAi and CRISPR/Cas9), biochemistry and cellular biology along with innovative quantitative imaging microscopy approaches and patient model systems to identify both genes and targets of interest.
Dr. McManus has published extensively in cancer genetics with a particular focus on chromosome instability, drug target discovery and therapeutic targeting (synthetic lethality) in many cancer types, including colorectal and ovarian cancers.
- Post-doctoral fellowship (Molecular Oncology), Michael Smith Laboratories, University of British Columbia (2009)
- PhD (Experimental Oncology), Cross Cancer Institute, University of Alberta (2004)
- Master of Science (Human Genetics), University of Manitoba (1999)
- Bachelor of Science (Honours Genetics), University of Manitoba (1995)
- Scientists’ Choice Award – Best Drug Discovery & Development Article of the Year (2016)
- University of Manitoba Graduate Student Association Teaching Award (2016)
- Merit Award for Research, Teaching and Service (2016)
- Ken Hughes Young Investigator Award for Medical Research (2014)
- Rh Award for Outstanding Contributions to Scholarship and Research in the Health Sciences (2014)
- Canadian Institutes of Health Research/Manitoba Health Research Council – New Investigator Salary Award (2010-12)
Visit Kirk McManus' ORCID profile for a complete listing, or find him on Google Scholar and ResearchGate.
Kirk McManus' profile