Malcolm Xing

Area

Biomaterials for tissue/organ repair, bioadhesion (bioglue) for sutureless surgery, hemorrhage management.

Expertise

1. Smart biomaterials
2. Tissue engineering
3. Nanomedicine
4. Biofabrication
5. Implantable sensor and biorobot

Research description

1. Tissue/organ repair
2. Smart hydrogel
3. Bioadhesion
4. Hemostasis
5. 4-D bioprinting

Dr. Xing is a Professor of biomaterials at the University of Manitoba, Winnipeg, Canada. He works on hydrogels and nanomedicine for tissue engineering, bioadhesives, hemostasis and biofabrication. He is also researching wearable and flexible electronic sensors. He published more than 190 papers, including Nature BME, Science Advances, Advanced Materials, ACS Nano, Biomaterials, Bioactive Materials, etc. He applied superelastic and intelligent hydrogels to myocardial infarction (Highlighted in Nature Review Cardiology), burns, cartilage and bone defects, and hair follicle reconstruction (American Chemical Society headline news and highlighted in Royal Society of Chemistry). He built the hydrophobic polymer chain’s entanglement system and applied it to the biological adhesive and hemostasis (highlighted by Matter). At the same time, he proposed the combination of adhesive and hemostasis to build a new bioglue system (highlighted as Science's This Week of Science and Nature Review Materials). His research in integrating adhesive with hemostasis of okra microgels was selected for Agence France Presse’s 2022 Nature Inspired solutions. Professor Xing develops materials for considering carbon-neutral and sustainable environments, which were recognized in Time magazine, Fortune, Science's Hot Research, American Chemical Society, etc. Dr. Xing is the fellow of the Canadian Academy of Engineering and American Institute for Medical and Biological Engineering.

He serves on the Editorial Board of 1) Bioactive Materials, 2) Burns & Trauma, 3) International Journal of Mechanical Sciences, 4) Regenerative Engineering and translational medicine.

1. Wang, L.#; Liu, Y. #; Ye, G. #; He, Y.; Li, B.; Guan, Y.; Gong, B.; Mequanint, K.; Xing, M.*; Qiu, X. *, Injectable and conductive patches for the repair of infarcted myocardium in rats and minipigs, Nature Biomedical Engineering, 2021, 5, 1157-1173.

2. Guo, Y.#; Wang, Y.#; Zhao, X.; Li, X.; Wang, Q.; Zhong, W.; Mequanint, K.; Zhan, R.*; Xing, M.*; Luo, G.*, Snake extract–laden hemostatic bioadhesive gel cross-linked by visible light, Science Advances, 2021,7, eabf9635.

3. Liu,Y.#; Guan, G.#;Li, Y.#; Tan, J.; Cheng,P.; Yang,M.; Li,B.;Wang,Q.; Zhong,W.; Kibret Mequanint,K.; Zhu,C.*; Xing,M.*, Gelation of highly entangled hydrophobic macromolecular fluid for ultra-strong underwater in-situ fast tissue adhesion, Science Advances, 2022, 8, eabm9744.

4. Zhou, Y*; Yang, L., Liu, Z.; Sun, Y.; Huang, J.; Liu,B.; Wang, Q.; Wang,L.*; Miao,Y.*, Xing, M.*; Hu, Z.*, Reversible adhesives with controlled wrinkling patterns for programmable integration and discharging, Science Advances, 2023, 9, eadf1043.

5. Liu, S.#; Luan, Z.#; Wang,T.; Xu,K.; Luo, Q.; Ye,S.; Wang,W.; Dan, R., Shu, Z., Huang, Y.; Mequanint, K; Fan,C.*;Xing,M.*; Yang*, S.,Endoscopy deliverable and mushroom-cap-inspired hyperboloid-shaped drug-laden bioadhesive hydrogel for stomach perforation repair, ACS Nano, 2023, 17, 111-126.