The current research program in my laboratory focuses on the cellular and molecular basis of immune responses to allergens and infectious agents and on the development of immunoprophylactic approaches for allergy and infectious diseases.
Project I . Study on hygiene hypothesis related to allergy/asthma. The objective of the study is to elucidate the mechanism underlying the long-term documented but unexplained mystery that as many countries reduce the burden of infectious diseases, a remarkable increase in the incidence of atopic allergies has occurred. Specifically, the project, using mouse models' is to study (I) the cellular and mechanisms by which bacterial and parasitic infections inhibit de novo and established allergic responses especially the roles of dendritic cells, NK/NKT cells, T cells and TLRs and various cytokines/chemokines; (ii) genetic factors influencing the manipulating effect of intracellular bacterial infections on allergic responses; and (iii) development of an engineered vaccine to universally inhibit atopic allergy.
Project II . Study of the protective immunity and immunopathology to chlamydial infection. The objective of the study is to dissect the cellular and molecular basis for chlamydial protective immunity and pathology. Specifically, this project will analyze: (I) the role of dendritic cells, NK/NKT cells, cytokines (chemokines) and adhesion molecules in the development or prevention of immunopathological responses; (ii) interaction of DC/NKT and DC/NK in chlamydial infections with a recent focus on the modulating effect of NKT/NK on the function of dendritic cells.
Project III . Development of vaccines for human chlamydial infection. The objective of the project is to develop a human vaccine against chlamydial infection. Various vaccination approaches including DNA vaccination and whole organism live mutant vaccine candidates are investigated.
For a list of Dr. Yang's PubMed articles, please click here
- X. Han, Y. Fan, S. Wang, J. Yang, X. Yang . Role of dendritic cells in infection mediated inhibition of airway inflammation. Eur J Immunol , 34:981-989, 2004. (Impact factor 4.772)
- L. Bilenki, Y. Fan, J. Yang, S. Wang and X. Yang . Natural killer T (NKT) cells contribute to airway eosinophilic inflammation induced by ragweed through enhanced IL-4 and eotaxin production. Eur J Immunol , 34:345-354, 2004. (Impact factor 4.772)
- Z. Ming, Y. Fan, X. Yang and W.W. Lautt. Blockade of intrahepatic adenosine receptors improves urine excretion in cirrhotic rats induced by thioacetamide. J. Hepatology, 42:680-6 , 2005. (Impact factor 6.073)
- L. Bilenki, S. Wang, J. Yang. Y. Fan, J. Gorge and X. Yang. N atural Killer T (NKT) cell activation promotes Chlamydia trachomatis infection in vivo J. Immunol. 175(5):3197-206. 2005. (Impact factor 6.293)
- S.R. Muhammad, L. Shan, J. Yang, H. Unruh, X. Yang , A. Halayko, Soussi Gounni A. IL-17 activation of ASM cells induces IL-6 and IL-8 expression via transcriptional mechanism. Clin. Immunol , 115:268-276, 2005. (Impact factor 3.606)
- Z. Ming, Y. Fan, X. Yang , and W.W. Lautt. Synergistic protection by s-adenosylmethionime with vitamins C and E on liver injury induced by thioacetamide in rats. Free Radical Biology & Medicine , 40(4):617-24, 2005. (Impact factor 5.44)
- X. Han, S. Wang, Y. Fan, J. Yang, L. Jiao, H. Qiu and X. Yang. Chlamydia infection induces ICOS -L expressing and IL-10 producing dendritic cells (DC) which can inhibit airway inflammation and mucus overproduction elicited by allergen challenge in BALB/c mice. J. Immunol. 176:5232-9, 2006. (Impact factor 6.293)
- Laura Bilenki, Shuhe Wang, Jie Yang, Yijun Fan, Lei Jiao, Antony George Joyee, X. Han and Xi Yang. Adoptive transfer of CD8a+ dendritic cells (DC) isolated from mice with Chlamydia trachomatis are more potent in inducing protective immunity than CD8a- DC. J. Immunol. 177:7067-75, 2006 (Impact factor 6.293)
- Ming Z, Y. Fan, X. Yang , W. Lautt, C ontribution of hepatic adenosine a1 receptors to renal dysfunction associated with acute liver injury in rats. Hepatology , 44:813-22, 2006 (Impact factor 10.446)
- Antony George Joyee, Hongyu Qiu, Shuhe Wang, Yijun Fan, Laura Bilenki and Xi Yang. Distinct NKT cell subsets are induced by different Chlamydia species leading to differential adaptive immunity and host resistance to the infections. J Immunol . 178(2):1048-58, 2007 (Impact factor 6.293)
- M. Al-Alwan, Q. Du, S. Hou, H. Nashed, Y. Fan, X. Yang , A. Marshall. Follicular dendritic cell-secreted protein ( FDC -SP) regulates B cell chemotaxis and germinal center responses. J Immunol , 178:7859-67, 2007. (Impact factor 6.293)
- Yanna Xiang, Shuhe Wang,William Ju, Mingyao Liu Jingxin Li, Yijun Fan, Bin Ye, Berley Orser, Xi Yang* and Wei-Yang Lu* (*Co-corresponding authors) . A GABAergic system in airway epitheliam is essential for mucus overproduction in asthma. Nature Medicine , 13:862-867, 2007 (Impact factor 28.588)
- Yanbing Ma, Kent HayGlass, Allan Becher, Sujata Basu, Yijun Fan, Andrew Halayko, Xi Yang , Ganesh Srinivasan, Estelle F. Simons, and Zhikang Peng. Novel IL-13 peptide-based vaccine suppresses airway allergic inflammatory responses in mice. Am. J. Respir. Crit. Care Med, 2007. (Impact factor 9.091)
- Xu G., Y. Fan, X. Yang , H. Korner, Fu X.Y., and J.E. Uzonna. Lymphotoxin alpha beta2 (LTaß2, membrane lymphotoxin) is critically important for resistance to Leishmania major infection in mice. J. Immunol. 179(8):5358-66 , 2007. (Impact factor 6.293)
- X. Han, Y. Fan, S. Wang, J. Yang, X. Yang . Natural killer cells contribute to intracellular bacterial infection-mediated inhibition of allergic responses J. Immunol. 180:4621-4628 , 2008. (Impact factor 6.293)
- Hongyu Qiu, Yijun Fan, Antony George Joyee, Shuhe Wang, Xiaobing Han, Hong Bai, Lei Jiao, Van Rooijin Nico and Xi Yang , Type 1 interferons enhance susceptibility to Chlamydia muridarum infection by reducing local infiltration, and enhancing apoptosis of macrophages. J. Immunol. 181 ( 3 ): 2092-102, 2008. (Impact factor 6.293)
- Antony George Joyee, Hongyu Qiu, Shuhe Wang, and Xi Yang . Natural killer T (NKT) cell activation influences dendritic cell function in host resistance to Chlamydia pneumoniae infection. Am. J. Respir. Crit. Care Med, 2008 Oct 1; 178 ( 7 ): 745-56 . Epub 2008 Jul 2. (Impact factor 9.091)
- L. Jiao, X. Han, S. Wang, Y. Fan, L. Bilenki, M. Yang, J. Yang, X. Yang . Neonatal exposure to bacterial products alter dendritic cell function in adulthood . Eur J. Immunol. Jan 2009, in press. (Impact factor 4.772)
LOOKING FOR GRADUATE STUDENTS (MASTERS, PhD, POST-DOCS) WITHIN THE NEXT YEAR
1 Post-Doc, 1 PhD Student