Research Interests:
Molecular pathogenesis on influenza virus, hepatitis viruses and coronaviruses; viral-host protein-protein interactions, signal transductions.

Publications:
1. Chiang S, Radziwon A, Cutts T, Dick K and He R. (2010). The T:G mismatch repair protein Thymine DNA glycosylase is an important regulation factor for nuclear receptor activation Mol Cell Biochem 333(1-2):221-32 .

2. Li C, Jaentschke B, Song Y, Wang J, Cyr TD, Van Domselaar G, He R, Li X (2010) A simple slot blot for the detection of virtually all subtypes of the influenza A viral hemagglutinins using universal antibodies targeting the fusion peptide. Nat Protoc. 2010;5(1):14-9. Epub

3. Hashem AM, Flaman AS , Farnsworth A, Brown EG, Van Domselaar G, He R, Li X. (2009) Aurintricarboxylic acid is a potent inhibitor of influenza A and B virus neuraminidases. PLoS One. 2009 Dec 17;4(12):e8350

4. Li X, Cyr TD, Girard M, Li C, Wang J, Van Domselaar G, Farnsworth A, MacDonald-Piquard H, and He R . (2009) Advances in quantitative analyses of the hemagglutinin of influenza A virus and vaccines. Global View of the Fight Against Influenza . Part II. Chapter 13. Nova Publishers p206-219

5. Tyler S, Andonov A, Cutts T, Grudesky E, Van Domselaar G, Li X and He R. (2009). The SR-rich domain of SARS-CoV nucleocapsid protein is important for the replication of the virus Can J Microbiol . 55(3):254-60

6. He R and Li X. (2008) Mammalian two-hybrid assay for detecting protein-protein interactions in vivo. Methods Mol Biol. 439:327-37

7. Huang D, Pereboev AV, Korokhov N, He R, Larocque L, Gravel C, Jaentschke B, Tocchi M, Casley WL, Lemieux M, Curiel DT, Chen W, Li X. (2008). Significant alterations of biodistribution and immune responses in Balb/c mice administered with adenovirus targeted to CD40(+) cells. Gene Ther . 15(4):298-308.

8. LeBrun M, Huang H, He R,Booth S, Balachandran A, Li X,. 2008.Trichloroacetic Acid Precipitation Improves Detection of Abnormal Prion Protein with Western Blot. Can J Microbiol . 54(6):467-71

9. Myskiw, C., Deschambault, Y., Jefferies, K., He, R., and Cao, J. (2007). Aurintricarboxylic Acid Inhibits the Early Stage of Vaccinia Virus Replication by Targeting both Cellular and Viral Factors. J.Virol. 81, 3027-3032

10. Beniac D, deVarennes S, Adonov A, He R and Booth T, (2007). Conformational Reorganization of the SARS Coronavirus Spike Following Receptor Binding: Implications for Membrane Fusion PLOs One . (2)10, 1802