Paul Marcogliese, PhD

Research summary

I am interested in the molecular and cellular mechanisms underlying neurological disease. While the etiology of diseases like Autism Spectrum Disorder (ASD) and Parkinson’s disease is complex, the study and identification genes responsible for rare disorders can offer insight into more common conditions. We primarily use a range of techniques in Drosophila melanogaster (fruit flies) to assess the functional consequences of the patient variants in vivo. Additionally, rapid generation of Drosophila with strong loss of function alleles in these genes provides a phenotyping and screening platform for unravelling biological mechanisms and drug testing.