Dr. Ute Stroher
 

Head, Molecular Virology & Antiviral Approaches Unit, Special Pathogens Program, National Microbiology Laboratory

Adjunct Professor, Department of Medical Microbiology, University of Manitoba

Degrees: Ph.D., University of Marburg , Germany

Mailing Address: National Microbiology Laboratory, 1015 Arlington Street , Winnipeg , Manitoba R3E 3R2 .

Tel: (204) 789-5070 Fax: (204) 789-2140 Lab: (204)789-5017
E-mail: Ute.Stroeher@phac-aspc.gc.ca

Research Interests:
Biosafety level 4 viruses (with focus on Filoviridae and Arenaviridae ): Molecular virology, reverse genetics, pathogenesis & antiviral strategies.

Recent Publications:
  1. Dolnik O, Volchkova V, Garten W, Carbonnelle C, Becker S, Kahnt J, Stroher U, Klenk HD, Volchkov V: Ectodomain shedding of the glycoprotein GP of Ebola virus. Embo J 2004, 23: 2175-2184.

  2. Feldmann H, Wahl-Jensen V, Jones SM, Stroher U: Ebola virus ecology: a continuing mystery. Trends Microbiol 2004, 12: 433-437.

  3. Garbutt M, Liebscher R, Wahl-Jensen V, Jones S, Moller P, Wagner R, Volchkov V, Klenk HD, Feldmann H, Stroher U: Properties of replication-competent vesicular stomatitis virus vectors expressing glycoproteins of filoviruses and arenaviruses. J Virol 2004, 78: 5458-5465.

  4. He R, Leeson A, Ballantine M, Andonov A, Baker L, Dobie F, Li Y, Bastien N, Feldmann H, Strocher U, et al: Characterization of protein-protein interactions between the nucleocapsid protein and membrane protein of the SARS coronavirus. Virus Res 2004, 105: 121-125.

  5. Stroher U, DiCaro A, Li Y, Strong JE, Aoki F, Plummer F, Jones SM, Feldmann H: Severe acute respiratory syndrome-related coronavirus is inhibited by interferon- alpha. J Infect Dis 2004, 189: 1164-1167.

  6. Geisbert TW, Jones S, Fritz EA, Shurtleff AC, Geisbert JB, Liebscher R, Grolla A, Stroher U, Fernando L, Daddario KM, et al: Development of a new vaccine for the prevention of Lassa fever. PLoS Med 2005, 2: e183.

  7. Jones SM, Feldmann H, Stroher U, Geisbert JB, Fernando L, Grolla A, Klenk HD, Sullivan NJ, Volchkov VE, Fritz EA, et al: Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses. Nat Med 2005, 11: 786-790.

  8. Wahl-Jensen V, Kurz SK , Hazelton PR, Schnittler HJ, Stroher U, Burton DR, Feldmann H: Role of Ebola virus secreted glycoproteins and virus-like particles in activation of human macrophages. J Virol 2005, 79: 2413-2419.

  9. Wahl-Jensen VM, Afanasieva TA, Seebach J, Stroher U, Feldmann H, Schnittler HJ: Effects of Ebola virus glycoproteins on endothelial cell activation and barrier function. J Virol 2005, 79: 10442-10450.

  10. Daddario-DiCaprio KM, Geisbert TW, Geisbert JB, Stroher U, Hensley LE, Grolla A, Fritz EA, Feldmann F, Feldmann H, Jones SM: Cross-protection against Marburg virus strains by using a live, attenuated recombinant vaccine. J Virol 2006, 80: 9659-9666.

  11. Daddario-DiCaprio KM, Geisbert TW, Stroher U, Geisbert JB, Grolla A, Fritz EA, Fernando L, Kagan E, Jahrling PB, Hensley LE, et al: Postexposure protection against Marburg haemorrhagic fever with recombinant vesicular stomatitis virus vectors in non-human primates: an efficacy assessment. Lancet 2006, 367: 1399-1404.

  12. Hoenen T, Groseth A, Kolesnikova L, Theriault S, Ebihara H, Hartlieb B, Bamberg S, Feldmann H, Stroher U, Becker S: Infection of naive target cells with virus-like particles: implications for the function of ebola virus VP24. J Virol 2006, 80: 7260-7264.

  13. Stroher U, Feldmann H: Progress towards the treatment of Ebola haemorrhagic fever. Expert Opin Investig Drugs 2006, 15: 1523-1535.

  14. Towner JS, Khristova ML, Sealy TK, Vincent MJ, Erickson BR, Bawiec DA, Hartman AL, Comer JA, Zaki SR, Stroher U, et al: Marburgvirus genomics and association with a large hemorrhagic fever outbreak in Angola. J Virol 2006, 80: 6497-6516.

  15. Bockeler M, Stroher U, Seebach J, Afanasieva T, Suttorp N, Feldmann H, Schnittler HJ: Breakdown of paraendothelial barrier function during Marburg virus infection is associated with early tyrosine phosphorylation of platelet endothelial cell adhesion molecule-1. J Infect Dis 2007, 196 Suppl 2: S337-346.

  16. Feldmann H, Jones SM, Daddario-Dicaprio KM, Geisbert JB, Stroher U, Grolla A, Bray M, Fritz EA, Fernando L, Feldmann F, et al: Effective Post-Exposure Treatment of Ebola Infection. PLoS Pathog 2007, 3: e2.

  17. Groseth A, Hoenen T, Alimonti JB, Zielecki F, Ebihara H, Theriault S, Stroher U, Becker S, Feldmann H: In vitro evaluation of antisense RNA efficacy against filovirus infection, by use of reverse genetics. J Infect Dis 2007, 196 Suppl 2: S382-389.

  18. Jones SM, Stroher U, Fernando L, Qiu X, Alimonti J, Melito P, Bray M, Klenk HD, Feldmann H: Assessment of a vesicular stomatitis virus-based vaccine by use of the mouse model of Ebola virus hemorrhagic fever. J Infect Dis 2007, 196 Suppl 2: S404-412.

  19. Stroher U, Willihnganz L, Jean F, Feldmann H: Blockage of filoviral glycoprotein processing by use of a protein-based inhibitor. J Infect Dis 2007, 196 Suppl 2: S271-275.

  20. Lee AM, Rojek JM, Gundersen A, Stroher U, Juteau JM, Vaillant A, Kunz S: Inhibition of cellular entry of lymphocytic choriomeningitis virus by amphipathic DNA polymers. Virology 2008, 372: 107-117.