Molecular pathobiology is an emerging discipline focused on the application of the newest techniques of molecular biology to problems of pathology in the study and diagnosis of disease. My laboratory has two main research goals: (i) to identify the role of microRNA regulators of immunity in brain infections, and (ii) to increase our understanding of the mechanism of neuronal death in prion-induced neurodegeneration as a means to identify novel therapeutics and biomarkers.
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- A. Majer A, Medina SJ, Niu Y, Abrenica B, Manguiat KJ, Frost KL, Philipson CS, Sorensen DL, & S.A. Booth. Early Mechanisms of Pathobiology are Revealed by Transcriptional Temporal Dynamics in Hippocampal CA1 Neurons of Prion Infected Mice. PLoS Pathogens 8 (11):e1003002. (2012).
- A. Majer, K. Caligiuri & S.A. Booth. A user-friendly computational workflow for the analysis of miRNA deep sequencing data Methods Mol Biol. 2013;936:35-45.
- J. Liang, W. Wang, S. Medina, S.A. Booth & Q. Kong. Cellular Prion Protein Regulates Its Own α-Cleavage through ADAM8 in Skeletal Muscle. Journal of Biological Chemistry 87(20):16510-20 (2012)
- R. Saba, S. Gushue, R.L.C.H. Huzarewich, K. Manguiat, S. Medina, C. Robertson, S.A.Booth. MicroRNA 146a (miR-146a) is over-expressed during prion disease and modulates the innate immune response and the microglial activation state. PLoS One 7 (2):e30832. (2012)
- A. Majer, A. Singh-Boese & S. A. Booth. MicroRNA Regulation of Life and Death in the Central Nervous System: Implications for Treatment and Early Detection of Human Neurodegenerative Disorders. Regulatory RNAs, their basics, methods and applications, B. Mallik (eds.), Regulatory RNAs, Springer Verlag, 443-473, (2012)
- R.L.C. H. Huzarewich, S. Medina, C. Robertson, D. Parchaliuk & S. A. Booth. Transcriptional modulation in a leukocyte depleted splenic cell population during prion disease Journal of Toxicology and Environmental Health 74: (22-24):1504-20. (2011)
- Majer & S. A. Booth. Computational methodologies for studying non-coding RNAs relevant to central nervous system function and dysfunction. Special miRNA issue of Brain Research 1338:131-45. (2010)
- P. N. Giannopoulos, C. Robertson, J. Jodoin, H. Paudel, S. A. Booth, and A. C. LeBlanc. Phosphorylation of Prion Protein at Serine 43 Induces Prion Protein Conformational Change J. Neurosci. 29: 8743 – 8751. (2009)
- J. Liang, D. Parchaliuk, S. Medina, G. Sorensen, L. Landry, S. Huang, M. Wang, Q. Kong, S. A. Booth. Activation of p53-regulated pro-apoptotic signaling pathways in PrP-mediated myopathy. BMC Genomics. 10:201. (2009)
- R.Saba, C. Goodman, R. Huzarewich, C. Robertson, S.A. Booth. A miRNA signature of prion induced neurodegeneration. PLoS ONE. 2008;3(11):e3652. Epub 2008 Nov
- R. Saba, S.A. Booth. MicroRNA Profiling in CNS Tissue Using Microarrays in Current Perspectives in microRNAs (miRNA) Ying, Shao Yao (Ed.) VIII, 464 p. 32 (2008)
- G. Sorensen, S. Medina, D. Parchaliuk, C. Phillipson, C. Robertson, S.A. Booth. Comprehensive transcriptional profiling of prion infection in mouse models reveals networks of responsive genes. BMC Genomics, Mar 3;9:114. (2008).
- S. Huang, J. Liang, M. Zheng, X. Li, M. Wang, D. Vanegas, D. Wu, B. Chakraborty, A. Hays, K. Chen, S. Chen, S.A. Booth, M. Cohen, P. Gambetti, Q. Kong. Inducible over-expression of wild type prion protein in the muscles leads to a primary myopathy in transgenic mice. PNAS, 104, 6800-6805 (2007).