Transplantation and Cell Therapy
Our Faculty and research trainees are investigating the interaction of the immune system with transplanted organs or cells. Researchers are implementing improved donor matching with recipients needing kidney transplants based on sophisticated analyses of immune responses and are developing cell-based therapies for burn victims and cancer patients.

GUAN, Qingdong (PhD)
Lab Director

  • Study the immunopathogenesis and potential therapy for allergy, autoimmune diseases, tumors and hematopoietic stem cell transplantation, with focusing on immune regulatory cells and cytokines.
  • Develop potential cellular therapy for the treatment of cancers and non-malignant diseases (eg, autoimmune diseases, myogenic disease)
  • Explore early phase clinical trials of novel cellular and/or gene therapy for cancers and non-malignant diseases (eg, mesenchymal stromal/stem cells, chimeric antigen receptor (CAR)-T cells)
  • Study the roles of HLA in allogeneic hematopoietic stem cell transplantation.

Cellular Therapy Laboratory, CancerCare Manitoba
Manitoba Center for Advanced Cell and Tissue Therapy (GMP Facility)
Assistant Professor, Dept of Internal Medicine & Immunology, University of Manitoba
Member, Research Institute in Oncology and Hematology, CancerCare Manitoba

Phone: (204) 787-4299
Email: qguan@hsc.mb.ca 


The goal of my translational research program is to develop novel immune monitoring tools to optimize and personalize immunosuppression for kidney transplant patients and improve long-term health outcomes.  This bench-to-bedside approach encompasses discovery proteomics and transplant clinical trials.
HO, Juliet (MD, FRCPC)
Professor, Departments of Internal Medicine & Immunology
Sections of Nephrology & Biomedical Proteomics

Office Phone: (204) 787-3583
Email: jho@hsc.mb.ca 
Web Page


   

NICKERSON, Peter (BSc (Med), MD, FRCPC, FCAHS)
Professor, Internal Medicine and Immunology
Vice-Dean Research

Office Phone: (204) 789-3375
Email: Peter.Nickerson@umanitoba.ca 
Web Page


RAOUF, Afshin (PhD) 
Associate Professor 
Senior Scientist, RIOH
Reg. Med. Program Member

The overarching goal of our research program is to understand the role of tissue environment and the tissue resident immune cells in healing and response to therapy.
To this end, we are engaged in two major and fundamental projects:

  1. We use patient samples to recreate the tumour microenvironment and understand the immunobiology of breast cancer tumours, and the reasons behind inability of immune cells to detect and eliminate cancer cells
  2. Using primary human cells, we create wound healing models to examine the immune suppressive properties of mesenchymal stem cells and how they can be used to improve the chronic non-healing wounds

TFRI-PCRC Breast Cancer Research Group Co-Chair
MFBF Chair in Chronic Wound Healing & Stem Cell Therapy
Manitoba Breast Cancer Research Group Team Leader

Office Phone: (204) 975-7704
Email: Afshin.Raouf@umanitoba.ca   
Web Page


Dr. Wiebe is a transplant nephrologist with expertise in immunogenetics and the development of de novo donor-specific antibodies in renal transplantation. He has published on the clinical and pathologic risk factors for de novo donor-specific antibody development. He also has developed expertise in the quantification and identification of the HLA alloepitopes mismatched between donor and recipient HLA alleles and has published on the role these play as predictors of dnDSA development.

WIEBE, Chris (B.Sc., B.Sc Med, M.D., FRCPC)
Assistant Professor - Cross Appointee
Department of Internal Medicine

Office Phone: (204) 789-1151
Email: cwiebe@hsc.mb.ca