Zeiler Lab

Frederick A. Zeiler BSc MD PhD CIP FRCSC (Neurosurgery)

Frederick Zeiler is a Canadian neurosurgeon who was hired as a clinician-scientist at the University of Manitoba in 2019. He completed his BSc at the University of Manitoba, focused on applied mathematics and physical chemistry, holding National Sciences and Engineering Research Council (NSERC) summer research awards during this time. He went on to complete his medical school at the University of Manitoba, followed by his neurosurgery residency at the same institution, receiving certification in neurosurgery from the Royal College of Surgeons of Canada. Dr. Zeiler has also completed dedicated fellowship training in both: neurocritical care at the Montreal Neurological Institute, and the Royal College of Physicians and Surgeons of Canada (RCPSC) clinician investigator program at the University of Manitoba. Finally, he completed his PhD training at the University of Cambridge, with his studies focused on advanced multi-modal monitoring of cerebrovascular reactivity in adult moderate and severe traumatic brain injury (TBI), under the supervision of world experts in TBI research: Prof David Menon and Prof Marek Czosnyka. During his time in Cambridge, he was recognized as both a Royal College of Surgeons of Canada Travelling Fellow in Surgery and University of Cambridge International Trust Scholar for the entirety of his studies. Dr. Zeiler is the author of over 200 peer-reviewed manuscripts, abstracts and text book chapter publications, and recipient of numerous awards for academic accomplishments. Currently, Dr. Zeiler is an Assistant Professor and Director of Neurosurgery Research within the Section of Neurosurgery, while recently being awarded the Rudy Falk Clinician-Scientist Professorship at the University of Manitoba, and holding guest researcher appointments at the University of Cambridge and Karolinska Institute.


Research Focus

His clinical practice focuses on the management of cranial neurotrauma, with his newly developing research program in Winnipeg focused on the application of multi-modal invasive/non-invasive cranial physiologic monitoring for the continuous assessment of cerebral autoregulation, compensatory reserve, autonomics and signal entropy. This program will integrate complex high-frequency signal processing, with neuroimaging, serum/CSF/microdialysis protein and genetic biomarkers. The goal is to uncover the molecular mechanisms involved in impaired cerebrovascular reactivity in TBI, leading to the development of potential therapeutic targets directed at prevention and treatment of vascular dysfunction in TBI. This program maintains strong ongoing collaborative ties with many international centers including: University of Cambridge, Karolinska Institute, University of Helsinki and Maastricht University.


Current Opportunities

Currently there are opportunities for both MSc and PhD students in Anatomy and Cell Science, with projects focused on cerebral physiologic signal acquisition and processing healthy and traumatic brain injury patients. Students with interests/backgrounds in engineering, signal processing, computer science, medical and biological sciences are encouraged to apply. For more information regarding some of the available projects, see:  https://umanitoba.ca/faculties/health_sciences/medicine/units/surgery/research-overview.html


If interested, please email Dr. Zeiler at:  Frederick.Zeiler@umanitoba.ca