Associate Professor, Departments of Surgery, Pediatrics & Child Health and Physiology
Pediatric Surgeon/Scientist, Department of Surgery, Division of Pediatric Surgery, University of Manitoba and the Children’s Hospital Research Institute of Manitoba
I am a pediatric surgeon-scientist and my clinical interest concentrates on minimal invasive pediatric surgery and my research focuses on congenital anomalies in general and congenital diaphragmatic hernia (CDH) and abnormal lung development in particular. CDH is a developmental defect of the diaphragm and it affects one in 2000 - 3000 newborns. It accounts for approximately 8% of the known major birth defects. Every year approximately hundred babies are born with CDH in Canada. Although surgical closure of the diaphragmatic defect is relatively easy, children with CDH suffer from their abnormal lung development. The pathogenesis of CDH and abnormal lung development is currently unknown.
I have expertise in mechanisms of normal and abnormal lung development due to CDH. My laboratory focuses on the role of two microRNAs: miR -10a and miR-200b during normal and abnormal lung development due to CDH. In the near future I want to explore methods for prenatal therapeutic interventions to modulate the natural course of abnormal lung development and CDH to improve the outcome of babies born with this devastating anomaly. I strongly believe that by improving our understanding of lung development and CDH will positively influence the outcome of these babies.
AE402 Harry Medovy House