, MSc Student | Samantha Lee
, PhD Student | Doris Onuzulu
, MSc Student | Zahra Sepehri
, MSc Student
Tasnim Beacon, MSc Student
My epigenetics research interest would be to identify regions of enrichment of H3K4me3 histone modification domains in colon cancer cells by chromatin immunoprecipitation and next generation sequencing.
Samantha Lee, PhD Student
I am a PhD student in the Jones lab. My research involves examining the epigenetic mechanisms underlying the developmental origins of health and disease. Specifically, I am investigating how prenatal and early-life exposure to ambient air pollution alters DNA methylation patterns through childhood and identifying which of these patterns also contribute to the development of childhood allergenic phenotypes. Through this research I hope to gain a better understanding of the molecular mechanisms underlying altered childhood health outcomes. Ultimately, I hope that this data can be used to direct future research aiming to develop accessible methods to prevent or reverse the effects of early-life air pollutant exposure.
After completing my PhD I hope to find myself in a position where I can utilize my skills in computational biology, epigenetics, and genetics to increase our understanding of the molecular mechanisms underlying complex diseases and towards the development of more effective treatments and/or preventative measures.
Doris Onuzulu, MSc Student
I have about three years’ experience in developmental epigenetics. I initially became interested in epigenetics during my MSc degree because it is a relatively new field especially in Nigeria where I come from. For my master’s research, I investigated the effects of in utero aflatoxin B1 on tumor suppressor methylation because aflatoxin B1 exposure is a public health concern especially in the tropics. My current project is very similar but focuses on effects of maternal cigarette smoke exposure in mice. Cigarette smoking is still a cause for concern even with numerous campaigns against its use.I am especially interested in developmental origins of diseases because of the great plasticity of the in utero period. I plan to continue in this line of research as I believe very little is known about the epigenetic origins of childhood diseases and I can be a major contributor to that.
Zahra Sepehri, MSc Student
My epigenetic interest is about epigenetic processes that control normal growth and development and its deregulation in diseases such as cancer.