The Manitoba Epigenetic Network was established by Dr. Jim Davie to foster collaborative research in epigenetics. The Network will provide resources for those involved or interested in epigenetics.
RESEARCH IN EPIGENETICS
Epigenetics is the study of changes in the regulation of gene activity and expression that are not dependent on alterations in gene (DNA) sequence. Histone modifications such as acetylation, methylation, ubiquitination and phosphorylation to name a few, DNA modifications including methylation at cytosines, and RNA (both coding and non-coding) have roles in regulating epigenetic events, which decide whether genes are turned off or on. Epigenetic regulation of gene expression programs is very dynamic and may be altered by diet, environment and in disease states such as cancer. The fascinating feature of epigenetics is that these processes are reversible. Through the study of epigenetics, new therapies for treating disease have arisen and are now being used in the clinic.
SUPPORTING THE MANITOBA EPIGENETIC RESEARCH COMMUNITY
Research in epigenetics has seen major advances due in part to innovative new technologies, such as the ever advancing Next Generation Sequencers. Methodologies is epigenetics are also quickly evolving with single cell methodologies being realized. The knowledge and skills of the Manitoba epigenetic research community are diverse. It is our hope that the Network will foster collaboration and team building. In addition the Network site will provide the latest information about funding opportunities, methodology and meetings to aid epigenetic researchers.