Research Interests:
Our main interest is to develop and test novel vaccine platforms for different applications including the protection against emerging pathogens. The new vaccine platforms that are being generated and evaluated are mainly derived from viruses, pathogenic as well as non-pathogenic (e.g. HIV, Adenovirus, AAV). Our efforts focus on modifying existing viruses at the molecular level and/or creating hybrid viruses for safe and efficient stimulation of a protective immunity against different pathogens including containment Level (CL) 4 viruses. An ongoing objective is to evaluate each vaccine strategy with the intent of identifying immune mechanisms and requirements correlating with immune protection. These findings should facilitate future selection and development of safer and more efficient vaccine strategies

Recent Publications:

For a list of Dr. Kobinger's PubMed articles, please click here

1. Weingartl HM, Nfon C, Kobinger G. Review of ebola virus infections in domestic
   animals. Dev Biol (Basel). 2013;135:211-8. doi: 10.1159/000178495. Epub 2013 May
   14. PubMed PMID: 23689899.
2. Shedlock DJ, Aviles J, Talbott KT, Wong G, Wu SJ, Villarreal DO, Myles DJ,
   Croyle MA, Yan J, Kobinger GP, Weiner DB. Induction of Broad Cytotoxic T Cells by
   Protective DNA Vaccination Against Marburg and Ebola. Mol Ther. 2013 May 14. doi:
   10.1038/mt.2013.61. [Epub ahead of print] PubMed PMID: 23670573.
3. Chen L, Ao Z, Danappa Jayappa K, Kobinger G, Liu S, Wu G, Wainberg MA, Yao X.
   Characterization of antiviral activity of a benzamide derivative AH0109 against
   HIV-1 infection. Antimicrob Agents Chemother. 2013 May 13. [Epub ahead of print]
   PubMed PMID: 23669388.
4. Nfon CK, Leung A, Smith G, Embury-Hyatt C, Kobinger G, Weingartl HM.
   Immunopathogenesis of Severe Acute Respiratory Disease in Zaire
   ebolavirus-Infected Pigs. PLoS One. 2013 Apr 23;8(4):e61904. doi:
   10.1371/journal.pone.0061904. Print 2013. PubMed PMID: 23626748; PubMed Central
   PMCID: PMC3633953.
5. Qiu X, Wong G, Fernando L, Ennis J, Turner JD, Alimonti JB, Yao X, Kobinger
   GP. Monoclonal antibodies combined with adenovirus-vectored interferon
   significantly extend the treatment window in Ebola virus-infected guinea pigs. J
   Virol. 2013 Apr 24. [Epub ahead of print] PubMed PMID: 23616649.
6. Dong JC, Kobinger GP. Hypothesis driven development of new adjuvants: Short
   peptides as immunomodulators. Hum Vaccin Immunother. 2013 Apr 1;9(4). [Epub ahead
   of print] PubMed PMID: 23563510.
7. Puppo A, Bello A, Manfredi A, Cesi G, Marrocco E, Della Corte M, Rossi S,
   Giunti M, Bacci ML, Simonelli F, Surace EM, Kobinger GP, Auricchio A. Recombinant
   vectors based on porcine adeno-associated viral serotypes transduce the murine
   and pig retina. PLoS One. 2013;8(3):e59025. doi: 10.1371/journal.pone.0059025.
   Epub 2013 Mar 8. PubMed PMID: 23520549; PubMed Central PMCID: PMC3592811.
8. Grolla A, Jones S, Kobinger G, Sprecher A, Girard G, Yao M, Roth C, Artsob H,
   Feldmann H, Strong JE. Flexibility of mobile laboratory unit in support of
   patient management during the 2007 Ebola-Zaire outbreak in the Democratic
   Republic of Congo. Zoonoses Public Health. 2012 Sep;59 Suppl 2:151-7. doi:
   10.1111/j.1863-2378.2012.01477.x. PubMed PMID: 22958259.
9. Ogunremi O, Pasick J, Kobinger GP, Hannaman D, Berhane Y, Clavijo A, van
   Drunen Littel-van den Hurk S. A single electroporation delivery of a DNA vaccine
   containing the hemagglutinin gene of Asian H5N1 avian influenza virus generated a
   protective antibody response in chickens against a North American virus strain.
   Clin Vaccine Immunol. 2013 Apr;20(4):491-500. doi: 10.1128/CVI.00577-12. Epub
   2013 Jan 30. PubMed PMID: 23365205; PubMed Central PMCID: PMC3623422.
10. Kuhn JH, Bao Y, Bavari S, Becker S, Bradfute S, Brister JR, Bukreyev AA, Caì
    Y, Chandran K, Davey RA, Dolnik O, Dye JM, Enterlein S, Gonzalez JP, Formenty P,
    Freiberg AN, Hensley LE, Honko AN, Ignatyev GM, Jahrling PB, Johnson KM, Klenk
    HD, Kobinger G, Lackemeyer MG, Leroy EM, Lever MS, Lofts LL, Mühlberger E,
    Netesov SV, Olinger GG, Palacios G, Patterson JL, Paweska JT, Pitt L, Radoshitzky
    SR, Ryabchikova EI, Saphire EO, Shestopalov AM, Smither SJ, Sullivan NJ,
    Swanepoel R, Takada A, Towner JS, van der Groen G, Volchkov VE, Wahl-Jensen V,
    Warren TK, Warfield KL, Weidmann M, Nichol ST. Virus nomenclature below the
    species level: a standardized nomenclature for laboratory animal-adapted strains
    and variants of viruses assigned to the family Filoviridae. Arch Virol. 2013 Jan
    29. [Epub ahead of print] PubMed PMID: 23358612.
11. Fouchier RA, García-Sastre A, Kawaoka Y, Barclay WS, Bouvier NM, Brown IH,
    Capua I, Chen H, Compans RW, Couch RB, Cox NJ, Doherty PC, Donis RO, Feldmann H,
    Guan Y, Katz JM, Kiselev OI, Klenk HD, Kobinger G, Liu J, Liu X, Lowen A,
    Mettenleiter TC, Osterhaus AD, Palese P, Peiris JS, Perez DR, Richt JA,
    Schultz-Cherry S, Steel J, Subbarao K, Swayne DE, Takimoto T, Tashiro M,
    Taubenberger JK, Thomas PG, Tripp RA, Tumpey TM, Webby RJ, Webster RG.
    Transmission studies resume for avian flu. Science. 2013 Feb 1;339(6119):520-1.
    doi: 10.1126/science.1235140. Epub 2013 Jan 23. PubMed PMID: 23345603.
12. Richardson JS, Pillet S, Bello AJ, Kobinger GP. Airway delivery of an
    adenovirus-based Ebola virus vaccine bypasses existing immunity to homologous
    adenovirus in nonhuman primates. J Virol. 2013 Apr;87(7):3668-77. doi:
    10.1128/JVI.02864-12. Epub 2013 Jan 9. PubMed PMID: 23302894; PubMed Central
    PMCID: PMC3624216.
13. Nfon C, Berhane Y, Pasick J, Embury-Hyatt C, Kobinger G, Kobasa D, Babiuk S.
    Prior infection of chickens with H1N1 or H1N2 avian influenza elicits partial
    heterologous protection against highly pathogenic H5N1. PLoS One.
    2012;7(12):e51933. doi: 10.1371/journal.pone.0051933. Epub 2012 Dec 11. PubMed
    PMID: 23240067; PubMed Central PMCID: PMC3519904.
14. Weingartl HM, Embury-Hyatt C, Nfon C, Leung A, Smith G, Kobinger G.
    Transmission of Ebola virus from pigs to non-human primates. Sci Rep. 2012;2:811.
    doi: 10.1038/srep00811. Epub 2012 Nov 15. PubMed PMID: 23155478; PubMed Central
    PMCID: PMC3498927.
15.  Wong G, Richardson JS, Pillet S, Patel A, Qiu X, Alimonti J, Hogan J, Zhang
    Y, Takada A, Feldmann H, Kobinger GP. Immune parameters correlate with protection
    against ebola virus infection in rodents and nonhuman primates. Sci Transl Med.
    2012 Oct 31;4(158):158ra146. doi: 10.1126/scitranslmed.3004582. PubMed PMID:
    23115355..