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Research Interests:
My research focuses on determining the mechanisms
by which human breast cancer cells progress from estrogen dependence to
independence and how breast cancers develop resistance to antiestrogens and
other endocrine therapies. A goal is to determine the types of estrogen
receptor expressed in human breast tissues (ER alpha, ER beta and their
variant isoforms) as well as their relevant coactivators and
corepressors. How these factors change during human breast tumorigenesis and breast
cancer progression is also a goal of the research. Additional research
interests include the interaction of progestins and antiprogestins with
human breast cancer cells, and most recently the identification and
characterization of genes differentially expressed between in situ
(preinvasive) breast cancer and invasive breast cancer, in order to
identify markers and eventually functional determinants of invasive
potential in in situ human breast cancer. My research although basic in
nature, encompasses a translational philosophy recognizing the need for
relevance to the breast cancer patient. Therefore, while working with
laboratory models of human breast cancer, much of my work now uses human
breast tissue samples and targets in situ approaches to assess the
heterogeneity of cellular composition inherent in these tissue samples.
Selected Publications:
- Lu B. Leygue E, Dotzlaw H, Murphy LJ, Murphy LC Functional
characteristics of a novel mouse estrogen receptor-beta isoform, estrogen
receptor beta2. J Mol Endocrinol: 25: 229-242, 2000. PMID
11013349
- Simon S, Parkes A, Leygue E, Dotzlaw H, Snell L, Troup S, Adeyinka A,
Watson P, Murphy LC Expression of REA in human breast tumors: relationship
to some known prognostic markers. Cancer Res 60: 2796-9, 2000.
PMID
10850416
- Murphy LC, Simon S, Parkes A, Leygue E, Dotzlaw H, Snell L, Troup S,
Adeyinka A, Watson P. Altered expression of estrogen receptor coregulators
during human breast tumorigenesis. Cancer Res: 60, 6266-6271, 2000.
PMID
11103781
- Al-Haddad S, Zhang Z, Leygue E, Snell L, Huang A, Niu Y, Hiller-Hitchcock
T, Hole K, Murphy LC, Watson PH. Psoriasin (S100A7) expression and invasive
breast cancer. Am J Pathol: 155: 2057-2066,. 1999. PMID
10595935
- Leygue E, Dotzlaw H, Watson PH, Murphy LC Expression of the steroid
receptor RNA activator (SRA) in human breast tumors. Cancer Res: 59:
4190-4193, 1999. PMID
10485452
- Dotzlaw, H., Leygue, E., Watson, P.H., Murphy, L.C. The human orphan
receptor PXR mRNA is expressed in both normal and neoplastic breast tissue.
Clin Cancer Res: 5, 2103-2107, 1999. PMID
10473093
- Leygue, E., Dotzlaw, H., Watson, P.H., Murphy, L.C. Expression of estrogen
receptor beta 1, beta 2 and beta 5 mRNAs in human breast tissue. Cancer
Res. 59: 1175-1179, 1999. PMID
10096542
- Dotzlaw, H., Leygue, E., Watson, P.H., Murphy, L.C. Estrogen
receptor-messenger RNA expression in human breast tumor biopsies:
relationship to steroid receptor status and regulation by progestin.Cancer
Res. 59: 529-532, 1999. PMID
9973194
- Leygue, E., Dotzlaw, H., Watson, PH., Murphy, L.C.Altered estrogen
receptor alpha and beta mRNA expression during human breast
tumorigenesis. Cancer Res. 58: 3197-3201, 1998. PMID
9699641
- Coutts, A., Murphy, L.C. Elevated mitogen-activated protein kinase
activity in estrogen non-responsive human breast cancer cells. Cancer Res.
58: 4071-4074, 1998. PMID
9751612
- Huang, A., Leygue, E., Snell, L., Murphy, L.C., Watson, P.H. Expression of
estrogen receptor variant mRNAs and determination of estrogen receptor
status in human breast cancer. Am. J. Pathol. 150: 1827-1833, 1997. PMID
9137105
- Leygue, E.R., Snell, L., Hiller, T., Watson, P.H., Murphy, L.C.
Differential expression of psoriasin (S100A7) mRNA between
in-situ and invasive human breast carcinoma. Cancer Res. 56: 4606-4609, 1996. PMID
8840971
PubMed
Listed Publications
Lab Members:
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