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Dr. Etienne Leygue
Associate
Professor, Department of Biochemistry and Medical Genetics
Degrees:
DEA Reproductive Physiology, (University
Pierre and Marie Curie, Paris, France 1990)
Ph.D, (University
Pierre and Marie Curie, Paris, France 1994)
Mailing Address:
Dept of Biochemistry and Medical Genetics
University of Manitoba
770 Bannatyne Avenue
Winnipeg, Manitoba, Canada R3E 0W3
Tel: (204) 977-5608
Fax: 789-3900
Lab: 789-3217
E-mail:
eleygue@cc.umanitoba.ca
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Research Interests:
My
research focuses on the study of gene expression during human
breast tumorigenesis. It is indeed believed that the knowledge
of the genetic changes that occur during the transition between
different pre-neoplastic and pre-invasive breast lesions and
that manifest themselves as alteration of gene expression, will
allow the identification of targets for new preventive and
curative strategies.
Two
genes, small breast epithelial mucin (SBEM) and steroid receptor RNA activator (SRA),
previously shown to be up-regulated in breast cancer compared to
normal breast tissue are currently studied in my laboratory.
Selected Publications:
- Cooper, C., Guo, J., Yan, Y., Chooniedass-Kothari, K.S., Hube, F., Hamedani, M.K., Murphy, L.C., Myal, Y., Leygue, E. Increasing endogenous relative expression of non-coding Steroid Receptor RNA Activator (SRA) in human breast cancer cells using modified oligonucleotides.
Nuc Acids. Res. 2009 May 29. [Epub ahead of print].
- Leygue, E. Steroid Receptor RNA activator (SRA1): unusual bi-faceted gene products with suspected relevance to breast cancer.
Review. Nuclear Recept. Sign. 5:e006, 2007.
- Hube, F., Guo, J., Chooniedass, K.S., Cooper, C., Hamedani, M.K., Wang, X., Dibrov A., Blanchard, A.A, Deng, G., Myal, Y., Leygue, E. Alternative splicing of the first intron of the steroid receptor RNA activator (SRA) participates in the generation of coding and non-coding RNA isoforms in breast cancer cell lines.
DNA Cell Biol, 25 (7): 418-428, 2006.
- Chooniedass-Kothari, S., Emberley, E., Hamedani, M., Troup, S., Wang, X., Czosnek, A., Hube, F., Mutawe, M., Watson, P.H., and Leygue, E. The steroid receptor RNA activator (SRA) is the first functional RNA encoding a protein.
Febs Letters, 566: 43-47, 2004.
- Miksicek, R.J, Myal, Y., Watson, P.H., Walker, C., Murphy, L.C., and Leygue, E. Identification of a novel breast- and salivary gland-specific, mucin-like gene strongly expressed in normal and tumor human mammary epithelium.
Cancer Res, 62: 2736-2740, 2002.
- Leygue, E., Dotzlaw, H., Watson, P. H., and Murphy, L. C. Expression of the steroid receptor RNA activator (SRA) in human breast tumors.
Cancer Res, 59: 4190-4193, 1999.
PubMed
Listed Publications
Lab Members:
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