Research Institute in Oncology and Hematology

Contact the GCCRD:

Ludger Klewes
ON6026-675 McDermot Ave
Winnipeg, Manitoba, Canada R3E 0V9
Phone: 204-787-2170 or 204-787-2760

Contact RIOH:

Research Institute in Oncology and Hematology
ON6026-675 McDermot Ave
Winnipeg, Manitoba, Canada R3E 0V9
Phone: 204-787-2137
Fax: 204-787-2190
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The Genomic Centre
                for Cancer Research and Diagnosis

Our Mission

The Genomic Centre for Cancer Research and Diagnosis (GCCRD) was created as a Regional/National Facility for all cutting edge imaging applications. The GCCRD is part of the Research Institute in Oncology and Hematology (RIOH), CancerCare Manitoba , and the University of Manitoba, in Winnipeg, Manitoba, Canada. It began with research into genomic instability and mechanisms of neoplasia, but has since expanded to meet various peoples with differing project needs. Activities of the GCCRD now include projects in molecular biology, cell biology, histopathology, and genetic diseases. The goals of the GCCRD are basic and translational research, as well as the education of students and highly qualified personnel in genomic instability, cancer genetics and imaging. The GCCRD was initiated by Dr. Sabine Mai. The facility was established through funds from the Canada Foundation for Innovation in 1999 amounting to $2.3 million dollars. Updates and new equipment are continually being added. It has since been fully supported by CancerCare Manitoba and for further information on funding see below. The GCCRD is equipped with state-of-the-art equipment and the technical capabilities of the GCCRD are diverse, but complementary, and they include:
  • Microscopy and imaging of live cells
  • Study of relative nuclear and cytosolic protein levels by quantitative fluorescent immuno-staining
  • Spectral karyotyping (SKY)
  • Spectral imaging
  • Comparative genomic hybridization (CGH)
  • Fluorescent in situ hybridization (FISH):
    • multicolour-FISH (M-FISH)
    • multicolour-Banding (m-Banding)
    • quantitative-FISH (Q-FISH)
  • Automatic slide scanning
  • Histology
  • Pathology
  • 3-Dimensional (3-D) imaging
  • Deconvolution
  • Laser chromosome micro-dissection
  • Confocal microscopy (LSM710)
  • Superresolution Microscopy
    • Structural Illumination Microscopy (SIM)
    • Photo Activated Localization Microscopy (PALM)
The GCCRD is also equipped with a teaching microscope for the training of diverse populations of students. This includes high school, summer, project, graduate, medical students and residents, as well as post doctoral fellows, and the advanced training of scientists. The Strategic Training Program Grant (Innovative Technologies in Multi-disciplinary Health Research Training) sponsored by the Canadian Institutes of Health Research (CIHR) makes it possible to hold a beginner workshop in the fall and an intermediate/advanced workshop the following spring; these workshops count as credits merited by the University of Manitoba. Please see our training program website for more details. GCCRD facility was funded four times through the Canada Foundation for Innovation (CFI) to a total of $13.7M. In addition to its other multifaceted capabilities, the GCCRD became the 3D Imaging Node for Canada in 2004. Scientific partners include:
  • The University of Manitoba
  • CancerCare Manitoba
  • CancerCare Manitoba Foundation
  • British Columbia Cancer Agency
  • Queens University, Kingston, Ontario, Canada
  • University of Toronto, The Hospital for Sick Children
  • McGill University, Jewish General Hospital
  • Tartu University Hospital, Tartu, Estonia
  • Microbiology and Tumour Biology Center, Karolinska Institute (Sweden)
  • Department of Clinical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;
  • Systems Biology Research Centre, School of Life Sciences, University of Skövde, Skövde, Sweden
  • Institute of Molecular Biology GmbH (IMB), Mainz, Germany
  • Prince of Songkla University Hospital, Hat Yai, Songkla, Thailand
  • Chiang Mai University (Thailand)
  • National Institutes of Health and National Cancer Institute (USA)
Corporate partners include:
  • VWR Scientific Products,
  • Sarstedt Inc.,
  • Cedarlane Laboratories Inc.,
  • Kindler GmbH & Co.,
  • Invitrogen Canada, Inc.,
  • Applied Spectral Imaging Inc.,
  • Empix Imaging Inc.,
  • MetaSystems Group Inc.,
  • Carl Zeiss Canada Ltd.,
  • Photonic Instruments Inc.
  • 3D Signatures Inc.
The Genomic Centre's educational component is comprised of endeavours with:
  • The Virtual Reality Centre, Winnipeg, MB
  • Pembina Trails School Division in Winnipeg
  • Städtisches Gymnasium Herzogenrath.

The GCCRD is a member of Canadian Cytometry and Microscopy Association.

GCCRD user committee members are Drs. Sabine Mai,James Davie, Spencer Gibson, James Johnston, Kirk McManus, Michael Mowat and Leigh Murphy.

RIOH gratefully acknowledges the generous support of

CCMB_Logo RIOH is a joint institute of CancerCare Manitoba and University of Manitoba UofM_Logo