MBTB Case Category Table

Manitoba Breast Tumor Bank Case Category Table

Case Element	Case Categories
	A	B	C	D	N
Cases
Approximate case numbers (total as of summer 2003 = 4500)	~660	~1500	~2200	~140	~70

Tissues
Matching paraffin & frozen tissue blocks	X	X	X	X	X
Matching paraffin & frozen blocks containing invasive tumor	X	X	X	X
Matching normal, in situ, invasive component available in some cases within tissue block	X	X	X	X
Matching normal, invasive, and nodal metastasis components available within separate tissue blocks	X
Time to collection data available	X

Data
Data on histological composition of sections	X	X	X	X
Data on case pathology	X	X	X	X
Data on case clinical staging and baseline	X	X	X
Data on case treatment	X	X
Data on case outcome	X	X

FOOTNOTES:

‘A-D’ are from tumor cases. ‘N’ are from normal cases (reduction mammoplasties)
‘A’ cases are associated with an established protocol (collection on ice, documentation of time from end of surgery to freezing of tissue) and multiple tissue samples (eg from normal breast from the surgical specimen, primary tumor, and axillary lymph nodes). Access to this category requires strong scientific justification and they are therefore not often provided.
'B, C, D’ category cases are mostly primary tumor samples and differ only in the extent of clinical data collected or extent of tissue available. ‘B’ cases have followup data available. ‘D’ cases derive from very large tumors with additional tissue blocks available for larger scale.
Cases in all categories can be selected on the basis of histological criteria (normal, in-situ, invasive and stromal components) and pathological criteria (type, grade size, ER/PR status). Grade is uniformly scored by a single pathologist using the Nottingham system. ER/PR is uniformly acquired by the provincial laboratory using the ligand binding assay.

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