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(PEDS-2) Temozolomide: current practice in pediatric brain tumors. A report of the Canadian Paediatric Brain Tumour Consortium (CPBTC)
U Bartels*, (Toronto, Ontario), AS Carret (Montreal, Quebec), B Crooks (Halifax, Nova Scotia), J Hukin (Vancouver, British Columbia), D Johnston (Ottawa, Ontario), M Silva (Kingston, Ontario), D Strother (Calgary, Alberta), B Wilson (Edmonton, Alberta), S Zelcer (London, Ontario), S Baruchel (Toronto, Ontario), E Bouffet (Toronto, Ontario)

(PEDS-4)  The Canadian Paediatric Brain Tumour Consortium (CPBTC): a model of cooperation using teleconferencing services
E Bouffet*, (Toronto, Ontario), AS Carret (Montreal, Quebec), B Crooks (Halifax, Nova Scotia), J Hukin (Vancouver, British Columbia), D Eisenstat (Winnipeg, Manitoba), B Wilson (Edmonton, Alberta), I Odame (Hamilton, Ontario), S Zelcer (London, Ontario), D Johnston (Ottawa, Ontario), M Silva (Kingston, Ontario), C Mpofu (Saskatoon, Saskatchewan), Y Samson (Quebec, Quebec), J Brossart (Sherbrooke, Quebec), A Moghrabi (Montreal, Quebec), D Strother (Calgary, Alberta)

(PEDS-6)  Treatment and outcome of supratentorial primitive neuroectodermal tumors: a report from the Canadian Pediatric Brain Tumour Consortium
D. Johnston*, D. Keene (Ottawa, Ontario), L. Lafay-Cousin (Toronto, Ontario), P. Steinbok (Vancouver, British Columbia), A-S Carret (Montreal, Quebec), B. Crooks (Halifax, Nova Scotia), D. Strother (Calgary, Alberta), B. Wilson (Edmonton, Alberta), I. Odame (Hamilton, Ontario), D. Eisenstat (Winnipeg, Manitoba), C. Mpofu (Saskatoon, Saskatchewan), S. Zelcer (London, Ontario), A. Huang , E. Bouffet (Toronto, Ontario)

(PEDS-10) Carboplatin hypersensitivity reaction in pediatric low grade glioma (LGG) patients: a Canadian national experience
L Lafay-Cousin* (Toronto, Ontario), J Hukin (Vancouver, British Columbia), AS Carret( Montreal, Quebec), B Wilson (Edmonton, Alberta), S Zelcer (London, Ontario), D Strother (Calgary, Alberta), I Odame (Hamilton, Ontario), M Silva (Kingston, Ontario), D Johnson (Ottawa, Ontario), C Mpofu (Saskatoon, Saskatchuan), L Sung (Toronto, Ontario), E Bouffet (Toronto, Ontario).

(PEDS-12) Expression of p53, PDGFR-a, -β and MIB-1 in paediatric high grade astrocytoma
ML Liang* (Taipei, Taiwan), J Ma, JT Rutka and CE Hawkins (Toronto, Ontario)

Introduced by Dr. David Eisenstat

Children’s Hospital Foundation of Manitoba Lectureship
                             

Dr. Mark Kieran, Director, Pediatric Medical Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA

                                                                                                                (Concert Hall – 7^th Floor)
POSTER SESSION I    Basic Science / Medical / Pediatric / Quality of Life / Surgical Posters 

***See list of poster presentations below

All posters will be displayed starting Friday, May 26 through Sunday, May 28. Posters can be mounted beginning at 1000 on Friday and must be taken down on Sunday by 1200.

PEDIATRIC NEURO-ONCOLOGY SESSION: B   (Crystal Ballroom)  
Co-Chairs:  Dr. Mark Kieran and Dr. Eric Bouffet

(BSC-5) Gene expression profiling of formalin fixed paraffin embedded samples in paediatric glioblastoma
T. Haque*, A. Nantel, D. Faury (Montreal, Quebec), E. Lopez-Aguilar (Mexico City, Mexico), S. Albrecht and N. Jabado (Montreal, Quebec).

(BSC-16) RECIPIENT OF THE YOUNG INVESTIGATOR AWARD IN CLINICAL RESEARCH CATEGORY. 

Presentation of the Award by Dr. James Perry (CBTC) and Alain Picard (Schering Canada)

HTERT expression predicts progression and survival in pediatric intracranial ependymoma.
U. Tabori^*, J. Ma, M. Carter, M. Zielenska, J. Rutka, E. Bouffet, U. Bartels, D. Malkin and C. Hawkins (Toronto, Ontario)

(BSc-17) The Role of Telomere Maintenance in the Spontaneous Growth Arrest of Pediatric Low Grade Gliomas.
U. Tabori*, B. Vukovic, M. Zielenska, C. Hawkins, I. Braude, J. Rutka, E. Bouffet, J. Squire, D. Malkin (Toronto, Ontario)

WELCOME RECEPTION – Hu’s On First Asian Bistro   
Casual Attire    

 Welcome Reception Speakers  

 Honourable Minister Tim Sale – Minister of Health, Province of Manitoba 
Dr. Peter Cattini, Associate Vice-President (Research) University of Manitoba 

Shuttle Bus Service to Hu’s On First:   Front Entrance of Fort Garry Hotel:      Departs 7:15 pm, 7:30 pm 
Return Shuttle Bus to Fort Garry Hotel:   Bus will wait outside Hu’s on First:   Departs 9:30 pm; 9:45 pm

BASIC SCIENCE SESSION:  A   (Crystal Ballroom – 7^th Floor)
Co-Chairs:  Dr. Spencer Gibson and Dr. Arie Perry

(BSc-3) Is PDGF-C a new genetic factor contributing to medulloblastoma formation?
Hao Ding* (Winnipeg, Manitoba)

(BSc-6) - RECIPIENT OF THE YOUNG INVESTIGATOR AWARD IN BASIC SCIENCE CATEGORY.

Presentation of the Award by Dr. James Perry (CBTC) and Alain Picard (Schering Canada)

Molecular and transformation properties of genetically modified synthetic astrocytes differentiated from embryonic stem (ES) cells in-vitro.
D. Kamnasaran*, C. Hawkins, A. Guha (Toronto, Ontario)

(BSc-7) GATA-6 is an astrocytoma tumor suppressor gene identified by gene trapping of  genetically engineered mouse glioma astrocytes.
D. Kamnasaran*, C. Hawkins, A. Guha (Toronto, Ontario)

(BSc-8) A combined epigenetic and genetic approach identifies novel tumor suppressor genes in medulloblastoma
PN Kongkham*, TG Mainprize, PA Northcott, Y Nakahara, MD Taylor, JT Rutka (Toronto, Ontario).

(BSc-9) Over-expression of MARKCS in EGFR amplified and EGFRvIII expressing glioblastoma multiforme (GBMs)
J. Micallef*, A. Guha (Toronto, Ontario)

(BSc-11) Identification of novel oncogenes and tumour suppressor genes in medulloblastoma using high-resolution single nucleotide polymorphism arrays
PA Northcott*, Y Nakahara, PN Kongkham, SW Scherer (Toronto, Ontario), W Grajkowska (Warsaw, Poland), GY Gillespie (Birmingham, Alabama), B Lach (Hamilton, Ontario), D Bigner (Durham, North Carolina), R Gilbertson (Memphis, Tennessee), JT Rutka and MD Taylor (Toronto, Ontario)

(BSc-12) Molecular genetic analysis of the benign and malignant components of Gangliogliomas.
A Pandita*, R. Perrin, A Balasubramanium and A Guha (Toronto, Ontario)

(BSc-14) Medulloblastoma invasion is inhibited by the Slit2-Roundabout1 signaling pathway 
M. Seyed Sadr*, T.E. Werbowetski-Ogilvie, V. Siu, N. Jabado (Montréal, Québec), J. Wu (Chicago, Illinois), R. Bjerkvig (Bergen, Norway), J.P. Antel, D. Faury (Montréal, Québec), Y. Rao (Chicago, Illinois), R.F. Del Maestro (Montréal, Québec)

(BSc-18) Hypoxia induces beclin-1 expression and autophagic cell death in apoptosis-competent glioma cells 
M. Webb*, Y. Chen, E. Henson, E. McMillan-Ward, S. Israels, and S.B. Gibson (Winnipeg, Manitoba)

(BSc-19) Identification of novel proteins that interact with neurofibromin.  
J.C. Wiley*, Z. Karim, A. Pandita, A. Guha (Toronto, Ontario)

(BSc-21) Defining the transcriptional program of c-Myc in medulloblastoma 
L.M. Zhou*, D. Picard, M. Li and Annie Huang (Toronto, Ontario).

                                                                                              Introduced by Dr. David Eisenstat
Brain Tumour Foundation of Canada Lectureship in honour of Dr. Rolando del Maestro

Dr. Arie Perry, Associate Professor, Division of Neuropathology, Director of Anatomic Pathology FISH Lab, Washington University School of Medicine

“Meningiomas: current classification and molecular features”

LUNCH 
                                                                                                            (Concert Hall – 7^th Floor)
POSTER SESSION II  Basic Science / Medical / Pediatric / Quality of Life / Surgical Posters  

***See list of poster presentations below

All posters will be displayed starting Friday, May 26 through Sunday, May 28. Posters can be mounted beginning at 1000 on Friday and must be taken down on Sunday by 1200.

RADIATION NEURO-ONCOLOGY SESSION  A   (Crystal Ballroom – 7^th Floor)
Co-Chairs:  Dr. Minesh Mehta and Dr. Glenn Bauman

(RAD-4) Simultaneous infield boost with helical tomotherapy for patients with 1-2 brain metastases
G. Bauman^*, S. Yartsev, B. Fisher (London, Ontario), T. Kron (Melbourne, Australia), N. Laperriere, M. Heydarian (Toronto, Ontario), L. Bailey, J. VanDyk (London, Ontario)

(RAD-6) The First Two Years of Gamma Knife Surgery in Winnipeg, Canada
A. M. Kaufmann*, M. West, G. Schroeder, D. Fewer, J. Nesbitt, and T. Bredin (Winnipeg, Manitoba), Winnipeg Centre for Gamma Knife Surgery

(RAD-8) Intermediate energy x-ray photons (0.2-1.0 MeV) for stereotactic radiosurgery applications: Demonstration of reduced penumbra
B. Keller*, J. Presutti, L. O’Malley, D. Beachey, M. Schwartz, J.P. Pignol (Toronto, Ontario)

(RAD-9) Radiosurgery for brain metastases: the McGill experience
E.M.C. Netto, L. Souhami,^,D. Roberge* (Montreal, Quebec)

(RAD-11) Accelerated Hypo-fractionation-IMRT (AH-IMRT) and Temozolomide (TMZ) in patients with Glioblastoma Multiforme (GBM):  A Novel Approach. 
G Shenouda^*, D Roberge, P Kavan, T Muanza, C Lambert, R Leblanc, R Del Maestro, MC Guiot, L Souhami (Montreal, Quebec)

(RAD-12) Spectroscopic imaging of Gamma-Knife-targeted neoplasms
M.N. Tran^*, S. Ronald, M. West, D. Eisenstat, L.N. Ryner (Winnipeg, Manitoba).

                                                                                            Introduced by Dr. David Eisenstat
Health Sciences Centre Foundation Lectureship

Dr. Minesh Mehta, Professor and Chair, Human Oncology, University of Wisconsin, Madison

“Innovative Radiotherapeutic Approaches for GBM”

                                                                                                              (Concert Hall – 7^th Floor)

POSTER SESSION III    Basic Science / Medical / Pediatric / Quality of Life / Surgical Posters  

***See list of poster presentations below

All posters will be displayed starting Friday, May 26 through Sunday, May 28. Posters can be mounted beginning at 1000 on Friday and must be taken down on Sunday by 1200.

Introduced by Dr. James Perry

The Crolla Family Brain Tumour Lectureship

Dr. Mitchell Berger, MD, Professor and Chair, Neurological Surgery, Director of Brain Tumor Research Centre, University of California, San Francisco

SURGICAL NEURO-ONCOLOGY SESSION    (Crystal Ballroom – 7^th Floor)
Chairs: Dr. Mitchell Berger and Dr. Anthony Kauffman

(SURG-1) Intra-operative fMRI tools in patients with brain tumours
R.F. Del Maestro*, P. Kostopoulos, C. Amiez, A. Champod, G. Koutrikas, M. Petrides, J. Dovan, D. Klein,  L. Soualmi, D. Collins (Montreal, Quebec)

(SURG-3) Neuro-oncological applications of neuro-endoscopy- The University of Manitoba Experience
P. McDonald* (Winnipeg, Manitoba)

(SURG-5) Functional magentic resonance imaging of tumors in speech areas
M Raja, SM Mirsattari, L Jong, F Bihari, D Lee, JF Megyesi* (London, Ontario)

(SURG-6) Potential candidates for a randomized trial of biopsy vs. resection in the management of adults with newly diagnosed malignant gliomas 
I.F. Parney^* (Calgary, Alberta), P. Forsyth (Calgary, Alberta), M. Eliasiw (Calgary, Alberta), M.G. Hamilton (Calgary, Alberta)

(SURG-7) Multispectral MR imaging for classification of low grade and malignant astrocytoma tissue with histopathological validation.
A. M. Wolf*, (Toronto, Ontario), A.P. Crawley (Toronto, Ontario), A. Guha (Toronto, Ontario)

(BSc-4) 5-FU delivered by means of blood-brain barrier disruption in F98-Fischer rats. 
Marie-Pierre Fournier-Gosselin*, Ana Maria Tsanaaclis, David Fortin (Sherbrooke, Quebec)

(BSc-10) Differential Regulators of Angiogenesis within GBMs.
J. Mukherjee*, A. Wolf, A. Pandita, and A. Guha (Toronto, Ontario),

Tumor Bank Meeting (Salon C- Main Floor)

(Concert Hall – 7^th Floor)

POSTER SESSION IV  Basic Science / Medical / Pediatric / Quality of Life / Surgical Posters  

***See list of poster presentations below

All posters will be displayed starting Friday, May 26 through Sunday, May 28. Posters can be mounted beginning at 1000 on Friday and must be taken down on Sunday by 1200.

BANQUET - The Club (Fort Garry Hotel Lower Level)

                                                                                                  Introduced by Dr. James Perry
MEDICAL NEURO-ONCOLOGY and QOL SESSION  (Crystal Ballroom)     

University of Toronto Peters Lectureship in Brain Tumour Research

Dr. Alfred Yung, MD, Chairman, Department of Neuro-Oncology, UT M.D. Anderson Cancer Center

“Targeting the P13K Pathway in Malignant Glioma”

MEDICAL NEURO-ONCOLOGY and QOL SESSION: A   (Crystal Ballroom – 7^th Floor)
Co-Chairs: Dr. Alfred Yung and Dr. James Perry

(MED-4) PRODIGE: A-phase III randomized placebo-controlled trial of thromboprophylaxis using dalteparin low molecular weight heparin (LMWH) in patients with newly diagnosed malignant glioma 
J. Perry*, L. Rogers, N. Laperriere, J. Julian, W. Geerts, G. Agnelli, M. Malkin, R. Sawaya, R. Baker, T. Finch, and M. Levine (Hamilton, Ontario

(MED-5) Adding Procarbazine when Temozolomide alone fails: a second-line oral regimen for adult gliomas.
F. Huang*, P. Kavan, M.C. Guiot, J. Markovic, D. Roberge^* (Montreal, Quebec)

(MED-6) Promising results from concurrent chemotherapy and whole brain radiation of brain metastases from lung cancer, a single institution phase II clinical study
C. Mihalcioiu* (Montreal, Quebec), S Navaratnam (Winnipeg, Manitoba)

(RAD-5) A Phase I Trial of Low-dose Cisplatin and Conformal Re-irradiation for Recurrent Malignant Glioma
B Fisher*, L Lukas, G Bauman, C Watling, D Macdonald (London, Ontario)

                                                                                                                (Concert Hall – 7^th Floor)

POSTER SESSION V  Basic Science / Medical / Pediatric / Quality of Life / Surgical Posters    (Concert Hall)

***See list of poster presentations below

MEDICAL NEURO-ONCOLOGY and QOL SESSION: B   (Crystal Ballroom – 7^th Floor)

(PEDS- 5) A novel web-based teaching tool to teach young minds neuro-oncology. 
P. Gfeller*, R. Harrison, K. Goddard (Vancouver, British Columbia)

(MED-1) Diurnal rest-activity rhythms following treatment for craniopharyngioma. 
K. Edelstein*, N. Laperriere, W. Mason (Toronto, Ontario)

(MED-2) An ethical framework for the complete care of patients with neuro-oncological diseases
K. Mukhida*, M. Bernstein (Toronto, Ontario)

Indications and Limitations of Neuropsychological Assessments in Pediatric and Adult Brain Tumour Patients.
Dr Kim Edelstein, Neuropsychologist, Princess Margaret Hospital, Toronto

Supporting patients and families through the experience of a brain tumour
Maureen Daniels, Princess Margaret Hospital, Toronto and Rosemary Cashman, BC Cancer Agency, Vancouver

POSTER PRESENTATIONS 

(PEDS-1) - Venous Thromboembolism in Children with Brain Tumours
A. Armstrong*, J. Duckworth, U. Athale, A. Chan and I. Odame (Hamilton, Ontario)

(PEDS-3) - Low grade gioma in chidren less than and equal to 12 month-old.
E. Bouffet*, U. Bartels, U. Tabori, V. Larouche, L. Lafay-Cousin, G. Nicolin, J. Rutka, A. Huang (Toronto, Ontario)

(PEDS-7) - National Epidemiological Survey of Pediatric CNS Germ Cell Tumors Occurrence in Canada
D. Keene^*, D. Johnston (Ottawa, Ontario), E. Bouffet (Toronto, Ontario), J. Brossard (Sherbrooke, Quebec), A. Carnet (Montreal, Quebec), B. Crooks (Halifax, Nova Scotia), D. Eisenstat (Winnipeg, Manitoba), C. Fryer (Vancouver, British Columbia), C. Mpofu (Saskatoon, Saskatchewan), A. Mogbrabi (Montreal, Quebec), I. Odama (Hamilton, Ontario), D. Strother (Calgary, Alberta), S. Zelcer (London, Ontario), R. Silva (Kingston, Ontario) and B. Wilson (Edmonton, Alberta)

(PEDS-8) - Use of ICE chemotherapy in pediatric choroid plexus carcinoma (CPC).
Lafay-Cousin*, U Bartels, P Dirks, A Gupta, A Huang, U Tabori, M Greenberg, S Weitzmann, E Bouffet (Toronto, Ontario)

(PEDS-9) - Neuroradiological finding of bleomycin extravasation in pediatric craniopharyngioma
Lafay-Cousin*, U Bartels, C Raybaud, A Kulkarni, A Huang, E Bouffet (Toronto, Ontario)

(PEDS-11) - Central Nervous System tumours in the first year of life: report of 83 cases.
V. Larouche*, L. Sung, L. Lafay-Cousin, U. Bartels, A. Huang, U. Tabori, J. Rutka, E. Bouffet (Toronto, Ontario)

(PEDS-13) - Telemedicine in paediatric neuro-oncology: King Hussein Cancer Center (Amman, Jordan) and the Hospital For Sick Children (Toronto Canada) experience
I. Qaddoumi, A. Mansour, A. Musharbash (Amman, Jordan), J. Drake (Toronto, Ontario), M. Sweedan, D. Odeh, M. Qudamat (Amman, Jordan) and E. Bouffet* (Toronto, Ontario)

(BSc-1) - Glioblastoma multiforme tumor cells can survive in hypoxic conditions by localizing BNIP3 to the nucleus
T.R. Burton*, D.D. Eisenstat, S.B. Gibson (Winnipeg, Manitoba)

(BSc-2) - Screening for tumour therapy sensitivity using an ex vivo invasion assay.
P. Costello*, W. McDonald, D. MacDonald, R. Hammond, J. Megyesi (London, Ontario)

(BSc-13) - Genetic alterations in the initiation and progression of NF1 deficient Schwann Cells in Peripheral Nerve Sheath Tumors (PNST).
A. Pandita*, L. Bereskin, J. Wiley, Z. Karim, A. Okhawat, P. Shannon and A. Guha(Toronto, Ontario)

(BSc-15) - Rac1 – A key mediator of astrocytoma migration and invasion
B. Salhia*, M. Symons, N. Tran, M. Berens, T. Mikkelson and J.T. Rutka (Toronto, Ontario)

(BSc-20) - The hypoxia inducible BCL-2 homologue BNIP3 is mutated in oligodendroglial tumours.
S. Zhang*, A. Perry (St. Louis, Missouri), F. Xue, E. Henson, S.B. Gibson and D.D. Eisenstat (Winnipeg, Manitoba) 

(BSc-22) - Tetrathiomolybdate(TM) suppresses tumour angiogenesis and distant metastases in animal model of head and neck cancer
B Hassouneh* (Hamilton, Ontario), M Islam (Ann Arbor, Michigan), T Nigel (Ann Arbor, Michigan), Q Pan (Ann Arbor, Michigan), S D Merajver (Ann Arbor, Michigan), T N Teknos (Ann Arbor Michigan)

(RAD-1) - Ranking of glioblastoma multiforme (GBM) cases into survival groups by multivariate analysis of clinical and treatment parameters.
O. Agboola;* S. Gertler;* M. McNulty (Ottawa, Ontario)

(RAD-2) - Radiotherapy induced GBM in management of Vestibular Schwannomas. - A case report and review of literature.
A. Balasubramaniam*, N. Laperriere, H. Michaels, A. Guha (Toronto, Ontario)

(RAD-3) - Neurological toxicity from stereotactic radiosurgery in patients treated for brain metastasis located in functional areas.
M. Barkati*, C. Lambert, A. Bouthillier, M-A. Fortin, J-P. Bahary, R.A. Moumdjian (Montreal, Quebec)

(RAD-7) - Gamma knife surgery for vestibular schwannomas: the first two years experience at the Winnipeg Centre for Gamma Knife Surgery
C. Kazina*, M. West, A. Kaufmann, D. Fewer, G. Schroeder (Winnipeg, Manitoba)

(RAD-10) - Transient Early-Delayed Reactions of Brain Irradiation  Mimicking Tumour Progression in High-Grade Malignant Gliomas 
N. S. Sandhu*, D. E. Rheaume (Halifax, Nova Scotia).

(SURG-2) The value of the extent of resection on the survival of patients bearing glioblastoma. 
M-P Fournier-Gosselin*, E. Cardin-Langlois, J-M Ouattara, A.M. Tsanaclis, D. Fortin (Sherbrooke, Quebec)

(SURG-4) The accuracy of neuroradiological diagnosis of non-traumatic intracranial mass lesions
CC DeSilva, R Hammond, DH Lee, A Leung, D Pelz, D Gorassini, JF Megyesi* (London, Ontario)

(MED-3) Dose-dense (D-D) continuous temozolomide (TMZ) combined with lomustine (CCNU) for first relapse of glioblastoma multiforme (GBM) after failure of standard concurrent chemoradiation
M. Morrison, J. Perry* (Toronto, Ontario)

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