Modeling and Design of Drug Delivery to Solid Tumors
(Rami Tzafriri, Harvard-MIT Division of Health)

Discrepancy between drug potency as observed in the laboratory and clinical efficacy is a recurrent problem in pharmaceutical science and is one of the major stumbling blocks in effective drug design. The last three decades have witnessed the development of sophisticated drug targeting controlled release technologies for overcoming and circumventing the "physiological barriers" to drug delivery. While these technologies have already impacted the treatment of many diseases, there is growing recognition in both academia and industry that the prevailing trial an error design of drug delivery techniques is a serious limiting factor and mathematical modeling has been suggested as an important tool in the design of drug delivery protocols.