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Vaccination
strategies that are optimal from an evolutionary standpoint need not
be optimal from an epidemiological standpoint. For example, perhaps
the strategy that is most likely to be successful in the absence of
evolutionary change is also the one that is most likely to lead to
adverse evolutionary outcomes. Can we predict when these sorts of
conflicts between evolutionary and epidemiological processes are likely?
If these sorts of conflicts do exist for vaccination strategies, how
can we weight the relative importance of evolutionary and epidemiological
issues in order to make informed decisions? |
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