DIMACS 2005

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Vaccination strategies that are optimal from an evolutionary standpoint need not be optimal from an epidemiological standpoint. For example, perhaps the strategy that is most likely to be successful in the absence of evolutionary change is also the one that is most likely to lead to adverse evolutionary outcomes. Can we predict when these sorts of conflicts between evolutionary and epidemiological processes are likely? If these sorts of conflicts do exist for vaccination strategies, how can we weight the relative importance of evolutionary and epidemiological issues in order to make informed decisions?