I obtained my B.S. in Applied Physics from Beijing University of Aeronautics and Astronautics (China) in 1998. This was followed by a M.S. in Physics from California State University-Fullerton in 2001. I received my Ph.D. in Physics in 2004 from the University of California-Irvine. From 2005 to 2008, I was a postdoctoral scholar at Stanford University. I have been with the Department of Physics and Astronomy at the University of Manitoba since December 2008.
My lab at the University of Manitoba studies environmental guiding mechanisms for the migration of biological cells with the focus on chemical and electrical cues. We primarily focus on the migration and trafficking of different leukocyte subsets and are extending the study to other cell types including cancer cells and stem cells. We leverage microfluidic devices in combination with cell biology, immunology and modeling approaches to these studies. In addition, we are developing microfluidic tools for a range of biological and biomedical applications through collaborations.
Selected Recent Publications
1. X. Wu, J.D. Wu, H.Z. Li, D.F. Legler, A.J. Marshall and F. Lin, “Analysis of CCR7 mediated T cell transfectant migration using a microfluidic gradient generator”, Journal of Immunological Methods, 2015, accepted.
2. K. Natarajan, C. Tian, B. Xiang, C. Chi, J.X. Deng, R.D. Zhang, D.H. Freed, R.C. Arora, G.H. Tian, F. Lin, “Selection of chemotactic adipose-derived stem cells using a microfluidic gradient generator”, RSC Advances, 2015, 5, 6332-6339.
3. S. Mahmood, S. Nandagopal, I. Sow, F. Lin and S.K.P. Kung, “Microfluidic-based, live-cell analysis allows assessment of NK-cell migration in response to cross-talk with dendritic cells”, European Journal of Immunology, 2014, 44(9):2737-48.
4. J.D. Wu, L.P. Ouyang, N. Wadhawana, J. Li, M. Zhang, S. Liao, D. Levin and F. Lin, "A compact microfluidic system for cell migration studies", Biomedical Microdevices, 2014, 16(4): 521-528.
5. J.D. Wu, X. Wu and F. Lin, “Recent Developments in Microfluidics-Based Chemotaxis Studies". Lab on a Chip (Canada Theme Issue). 2013, 13(13):2484-99.
6. D. Wu, X.L. Ma and F. Lin, "DC Electric Fields Direct Breast Cancer Cell Migration, Induce EGFR Polarization and Increase the Intracellular Level of Calcium Ion", Cell Biochemistry and Biophysics. 2013, 67 (3):1115-1125.
7. Li HZ, Hou S, Wu X, Nandagopal S, F. Lin, Kung S and Marshall A, “The tandem PH domain-containing protein 2 (TAPP2) is a novel mediator of cancer B cell migration controlling the actin cytoskeleton”, 2013. PLoS ONE. 2013;8(2):e57809.
8. N. Wadhawan, H. Kalkat, K. Natarajan, X.L. Ma, S. Gajjeraman, S. Nandagopal, N. Hao, J. Li, M. Zhang, J.X. Deng, B. Xiang, S. Mzengeza, D. Freed, R. Arora, G.H. Tian and F. Lin, “Growth and Positioning of Adipose-Derived Stem Cells in Microfluidic Devices”, Lab on a Chip. 2012, 12 (22), 4829-4834.
9. J. Li, L. Zhu, M. Zhang and F. Lin, "Microfluidic Device for Studying Cell Migration in Single or Co-Existing Chemical Gradients and Electric Fields", Biomicrofluidics, 2012, 6, 024121
10. J. Li and F. Lin, "Microfluidic Devices for Studying Chemotaxis and Electrotaxis", Trends in Cell Biology, 2011, Vol. 21, 489-497.
11. D. Wu and F. Lin, "Modeling Cell Gradient Sensing and Migration in Competing Chemoattractant Gradients", PLoS ONE, 2011, 6(4): e18805.
12. S. Neethirajan I. Kobayashi, M. Nakajima D. Wu, S. Nandagopal and F. Lin, "Microfluidics for Food, Agriculture and Biosystems Industries”, Lab on a Chip, 2011, 11 (9), 1574 - 1586.
13. S. Nandagopal, D. Wu (co-first author) and F. Lin, "Combinatorial Guidance by CCR7 Ligands for T Lymphocyte Migration in Co-Existing Chemokine Fields", PLoS ONE, 2011, 6(3): e18183.
14. J. Li, S. Nandagopal, D. Wu, S.F. Romanuik, K. Paul, D.J. Thomson and F. Lin, "Activated T Lymphocytes Migrate Toward the Cathode of DC Electric Fields in Microfluidic Devices", Lab on a Chip, 2011, 11(7), 1298 -1304.