Dr. Frank LaBella

Frank S. LaBella
Professor Emeritus- Department of Pharmacology and Therapeutics
University of Manitoba
B.A., M.A., Wesleyan University
Ph.D., Emory University
753 McDermot Avenue, Chown Building A406, Winnipeg, MB R3E 0T6
tel: (204) 789-3602; fax: (204) 789-3932
Email:  labella@shaw.ca  

Research Focus:

My research over the years has been in several areas:

Neuropharmacology; Narcotic drugs and endorphins; Mechanisms of general anesthesia; Neuroendocrinology; Neurochemistry; Neurotoxicology; Digitalis drugs; Receptor pharmacology; Aging; Cytochrome P450; Histamine as a second messenger; Novel technology to measure electromagnetic radiation.

Currently, I am focusing on research and development of a novel, patented technology, arising from a discovery made some years ago with Dr. Carl Pinsky. A company. FIND Technologies Inc.,  was established with the goal of commercializing the invention. http://www.biomedcanada.com/find-technologies.html

The FIND  Sensor detects electromagnetic energy that is emitted by all matter. The technology has a vast potential for practical applications, including uses in biology and medicine. The Sensor reacts to changes that may occur when scanning a structure or individual or when it is exposed to a substance or body or new environment. It can detect concealed hazardous materials.  Another  potentially vital use is determination of changes in biological and chemical activity or identification of growing, diseased and repairing tissues. 

 

Recent Publications

LaBella, F.S. and Brandes, L. INTERACTION OF HISTAMINE AND OTHER BIOAMINES WITH CYTOCHROME P450: IMPLICATIONS FOR CELL GROWTH MODULATION AND CHEMOPOTENTIATION BY DRUGS. Seminars in Cancer Biology 10 47-53, 2000.

Brandes, L., Queen, G. and LaBella, F.S. DISPLACEMENT OF HISTAMINE FROM LIVER CELLS AND CELL COMPONENTS BY LIGANDS FOR CYTOCHROMES P450. J. Cell Biochem. 85(4): 820-824, 2002.

Brandes, L. Queen, G. and LaBella, F.S. N,N-DIETHYL-2[4-(PHENYLMETHYL)PHENOXY] ETHANAMINE (DPPE), A CHEMOPOTENTIATING AND CYTOPROTECTIVE AGENT IN CLINICAL TRIALS: INTERACTION WITH HISTAMINE AT CYTOCHROME P450 3A4 AND OTHER ISOZYMES THAT METABOLIZE ANTINEOPLASTIC DRUGS. Cancer Chemother Pharmacol. 45: 298-304, 2000.

LaBella, F.S. and Brandes, L. INTERACTION OF HISTAMINE AND OTHER BIOMINES WITH CYTOCHROME P450: IMPLICATIONS FOR CELL GROWTH MODULATION AND CHEMOPOTENTIATION BY DRUGS. Seminars in Cancer Biology 10: 47-53, 2000.

LaBella, F.S., Queen, G., and Brandes, L. INTERACTIVE BINDING AT CYTOCHROME P-450 OF CELL GROWTH REGULATORY BIOAMINES, STEROID HORMONES, ANTIHORMONES, AND DRUGS. J. Cell. Biochem. 76: 686-694, 1999.

Labella, F.S., Stein, D. and Queen, G. "THE SITE OF GENERAL ANESTHESIA AND CYTOCHROME P450 MONOOXYGENASE: OCCUPATION OF THE ENZYME HEME POCKET BY XENON AND NITROUS OXIDE". European Journal of Pharmacology 381: R1-R3, 1999.

Labella, F.S., Stein, D. and Queen, G. "OCCUPATION OF THE CYTOCHROME P450 SUBTRATE POCKET BY DIVERSE COMPOUNDS AT GENERAL ANESTHESIA CONCENTRATIONS". European Journal of Pharmacology 358: 177-185, 1998.

Brandes, L.J., Queen, G.M. and Labella, F.S. "POTENT INTERACTION OF HISTAMINE AND POLYAMINES AT MICROSOMAL CYTOCHROME P450, NUCLEI AND CHROMATIN FROM RAT HEPATOCYTES". Journal of Cellular Biochemistry 69(3): 233-243, 1998.

Flip, D., Fournier,M., Benquet, C., Roux, P., LeBoulaire, C., Pinsky, C., Labella, F.S. and Krzystyniak, K. "INCREASED APOPTOSIS, CHANGES IN INTRACELLULAR Ca2+, AND FUNCTIONAL ALTERATIONS IN LYMPHOCYTES AND MACROPHAGES AFTER IN VITRO EXPOSURE TO STATIC MAGNETIC FIELD". Journal of Toxicology and Environmental Health - Part A 54(1): 63-76, 1998.

Labella, F.S. and Templeton, J.F. " PREGNANES THAT BIND TO THE DIGITALIS RECEPTOR". Clinical and Experimental Hypertension 20(5-6): 601-609, 1998.

Frank S. LaBella
Country	Number	Issue Year	Title
USA	5,144,017	1992	Compounds that bind to digitalis receptor.
USA	5,270,457	1993	Cardiac steroid glycosides.
USA	6,150,812	2000	Novel technology to measure electromagnetic radiation.
Europe	0746773	2000	Novel technology to measure electromagnetic radiation.