Professor - Department of Pharmacology and Therapeutics University of Manitoba
753 McDermot Avenue, Chown Building A311, Winnipeg, MB R3E 0T6
tel: (204) 789-3562 fax: (204) 789-3932
Email: rbose@ms.umanitoba.ca
Research Interests
1) Signal transduction in platelets from diabetic patients.
2) Excitation-contraction coupling in tracheal and vascular smooth muscle. Role of intracellular calcium , sodium and pH.
Selected References:
Roberts D., McNicol A. and R. Bose. Mechanism of collagen activation in human platelets. J. Biol. Chem. 2004, 279:19421-19430.
Bose R., Li Y. and D. Roberts. Na+/Ca2+ exchange in activated and non-activated platelets. Ann. NY Acad. Sci. 2002, 976:350-353.
Roberts D. and R. Bose. Reverse mode Na+/Ca2+ exchange in collagen activation of human platelets. Ann. NY Acad. Sci. 2002, 976:345-349.
Li Y., Woo V. and R. Bose. Platelet hyperactivity and abnormal calcium homeostasis in Diabetes Mellitus. Am. J. Physiol. 2001, 280:H1480-H1489.
Guia A., LeBlanc N. and R. Bose. Effect of phenamil on potassium and calcium channels of guinea-pig ventricular myocytes. J. Pharmacol. Exper. Therap., 1995, 274:649-656.
Guia A., Chau T., Bose D. and R. Bose. Mechanism of cardiac inotropy by phenamil, an epithelial sodium channel blocker. J. Pharmacol. Exper. Therap. 1996, 277:163-173.
Yu J., Ong B.Y., Zheng J., Cragoe E.J., Bose D. and R. Bose. Effect of anion exchange on intracellular pH and tension in canine basilar artery of dogs. Am. J. Physiol. 1996, H1912-H1917.
Ratna Bose